Study on Synthesis Technology of Chloroquine Phosphate
The synthesis process of chloroquine phosphate was studied to solve the problems of high pollution,low yield and poor quality.4,7-dichloroquinoline was used as starting material to directly condense with 2-amino-5-diethylaminopentane,and an HPLC intermediate control method was introduced to monitor the reaction process.Chloroquine phosphate was prepared from chloroquine condensation liquid by a method of removing impurities and then directly salt it with phosphoric acid.Avoid the use of highly toxic solvents and catalysts,HPLC intermediate control test to ensure complete reaction;The purity of chloroquine phosphate was over 99.8％.The condensation solution of chloroquine was combined with phosphoric acid to form salt,and the yield was also improved.The improved process has the advantages of green environmental protection,simple operation,high yield and good product quality,and is more suitable for industrial production.
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维普
