Fe3O4 nanoparticles with a core-shell structure were synthesized using a straightforward two-step method,in which Fe3O4 nanoparticles served as the core and 1,3,5-Triformylbenzene and 4,4'-diaminodiphenyldisulfide acted as monomers.The structure of Fe3O4@COF was characterized through scanning and transmission electron microscopy,infrared spectroscopy,X-ray powder diffraction,thermogravimetry,and magnetometry.The results demonstrate that the surface of the Fe3O4 nanoparticles was uniformly coated with a highly crystalline COF shell,with a particle size of approximately 200 nm.Following the loading of doxorubicin,the interaction between glutathione and the disulfide bonds in 4,4'-diaminodiphenyldisulfide facilitated the dissolution of the COF shell,leading to rapid drug release.
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