首页|具有还原响应性的磁性Fe3O4@COF的构筑及其负载和递送阿霉素性能研究

具有还原响应性的磁性Fe3O4@COF的构筑及其负载和递送阿霉素性能研究

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以Fe3O4 纳米粒子为内核,均苯三甲醛和 4,4'-二硫代二苯胺为单体,通过简易的两步法合成了具有核-壳结构的Fe3O4@COF纳米粒子,再利用扫描/透射电子显微镜、红外光谱、X射线粉末衍射、热重和磁强计对其结构进行表征.结果表明,Fe3O4纳米粒子表面均匀生长了高结晶度的COF壳层,整个粒子的粒径为200 nm左右.负载阿霉素后,在谷胱甘肽存在的酸性条件下,通过谷胱甘肽与 4,4'-二硫代二苯胺中二硫键的相互作用,达到了COF壳层解体及快速释放药物的效果.
Construction of Redox-responsive Magnetic Fe3O4@COF and Its Performance in Loading and Delivery of Doxorubicin
Fe3O4 nanoparticles with a core-shell structure were synthesized using a straightforward two-step method,in which Fe3O4 nanoparticles served as the core and 1,3,5-Triformylbenzene and 4,4'-diaminodiphenyldisulfide acted as monomers.The structure of Fe3O4@COF was characterized through scanning and transmission electron microscopy,infrared spectroscopy,X-ray powder diffraction,thermogravimetry,and magnetometry.The results demonstrate that the surface of the Fe3O4 nanoparticles was uniformly coated with a highly crystalline COF shell,with a particle size of approximately 200 nm.Following the loading of doxorubicin,the interaction between glutathione and the disulfide bonds in 4,4'-diaminodiphenyldisulfide facilitated the dissolution of the COF shell,leading to rapid drug release.

covalent organic frameworkmagnetic nanoparticlesanticancer nanomedicineredox response

刘佩玲、李维、曹兢

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湖南理工学院 化学化工学院,湖南 岳阳 414006

岳阳市检验检测中心,湖南 岳阳 414006

共价有机框架 磁性纳米粒子 抗癌纳米药物 还原响应性

湖南省自然科学基金青年项目湖南省教育厅优秀青年项目

2021JJ4022420B271

2024

湖南理工学院学报(自然科学版)
湖南理工学院

湖南理工学院学报(自然科学版)

影响因子:0.259
ISSN:1672-5298
年,卷(期):2024.37(3)