线粒体的力学生物学研究进展
Research Progress on Mechanobiology of Mitochondria
纳静 1郑丽沙 1樊瑜波1
作者信息
- 1. 北京航空航天大学生物与医学工程学院;生物力学与力生物学教育部重点实验室;北京市生物医学工程高精尖创新中心,北京 100083
- 折叠
摘要
线粒体是高度动态的细胞器,不仅为细胞提供能量和物质基础,同时参与调控细胞的增殖、迁移、分化和凋亡等.细胞命运受来自微环境的力学信号调节.近年来的研究表明,力学因素对细胞的能量代谢具有调控作用.线粒体作为一个力学感受器和枢纽,连接力学和代谢来调控细胞的命运.深入理解力学微环境和线粒体代谢的关系,为促进组织再生和疾病治疗提供有力的指导.本文主要介绍线粒体力学生物学研究进展,并探讨其在组织再生和疾病治疗中的潜在应用.
Abstract
Mitochondria are highly dynamic organelles,which not only provide energy and material basis for cells,but also regulate cell proliferation,migration,differentiation,and apoptosis.Cell fate is regulated by mechanical cues from the microenvironment.Recent studies have shown that energy metabolism is regulated by mechanical cues.Mitochondria can act as mechanical sensors and hubs that connect the mechanics and metabolism to regulate cell fate.A deep understanding of the relationship between the mechanical microenvironment and mitochondrial metabolism provides sufficient guidance for promoting tissue regeneration and treating diseases.In this review,the progression in mitochondrial mechanobiology is mainly introduced and its potential applications in tissue regeneration and disease treatment are explored.
关键词
线粒体/力学微环境/力学转导/组织再生/癌症Key words
mitochondria/biomechanical microenvironment/mechanotransduction/tissue regeneration/cancer引用本文复制引用
基金项目
北京市自然科学基金-昌平创新联合基金(L234072)
国家自然科学基金项目(32171310)
国家自然科学基金项目(11972067)
国家自然科学基金项目(12332019)
国家自然科学基金项目(U20A20390)
出版年
2024
NETL
NSTL
万方数据