摘要
目的 预测大鼠股骨皮质骨微观能量释放率,探究微观能量释放率随大鼠月龄的变化关系.方法 依托前期实验数据,结合皮质骨断裂模拟数值方法,对比仿真与实验测得载荷-位移曲线及断裂模式,反演预测不同月龄大鼠股骨皮质骨的微观能量释放率.结果 经预测得到 1、3、5、7、9、11、15 月龄大鼠股骨皮质骨微观能量释放率分别处于 0.08～0.12、0.12～0.14、0.15～0.19、0.25～0.28、0.23～0.25、0.19～0.22、0.13～0.16 N/mm.结论 微观能量释放率随月龄增长而下降导致失效载荷降低,说明微观能量释放率是决定骨折发生的主要因素之一,但断裂时刻却未观察到明显下降,说明微观能量释放率与结构断裂时刻未呈线性正比关系.研究结果 能够从临床层面协助解释皮质骨的骨折发生机制.
Abstract
Objective To predict the micro-level energy release rate in the rat femoral cortical bone and investigate the variation in the micro-level energy release rate with age.Methods Based on previous experimental data and numerical simulation of fracture modes for cortical bone,load-displacement curves and fracture modes measured by simulation and experiment were compared,and the micro-level energy release rates of rat femoral cortical bone at different months were predicted by back-calculation.Results It was predicted that the micro-level energy release rate of rat femoral cortical bone at 1-,3-,5-,7-,9-,11-,and 15-month age was 0.08-0.12,0.12-0.14,0.15-0.19,0.25-0.28,0.23-0.25,0.19-0.22,and 0.13-0.16 N/mm,respectively.Conclusions The decrease in the microlevel energy release rate with increasing age led to a decreasing failure load,indicating that the microlevel energy release rate is one of the main factors determining fracture occurrence;however,no significant decrease was observed at the time of fracture,indicating that the microlevel energy release rate was not linearly proportional to the fracture time.These results can help explain the mechanism of cortical bone fractures at the clinical level.
基金项目
吉林省自然科学基金(YDZJ202301ZYTS250)
江苏省工程技术研究开发中心项目()
NETL
NSTL
万方数据