软组织再生力医学
Mechanomedicine for Soft Tissue Regeneration
师念园 1马玉菲 1徐峰1
作者信息
- 1. 西安交通大学 生命科学与技术学院,生物医学信息工程教育部重点实验室;仿生工程与生物力学研究所,西安 710049
- 折叠
摘要
创伤、疾病和衰老造成的软组织、器官缺损或衰退对人类健康带来极大负担,软组织再生技术为解决上述问题带来了希望.近年来,随着生物力学、力学生物学与再生医学多学科交叉研究日益深入,力学逐渐成为调控软组织再生的关键因素之一.尽管如此,目前临床对于软组织的力学特性缺乏深入认识,也未完全掌握其在软组织疾病诊疗及软组织缺损修复中的潜在价值.本文通过总结国内外相关研究进展,提出"软组织再生力医学"这一概念.随后,从软组织多尺度生物力学、软组织再生力学生物学、软组织再生力医学技术及软组织再生力医学应用4 个方面,系统描述力学因素对软组织发育和再生的影响机制.最后,对力医学应用于临床软组织疾病诊疗及软组织缺损修复的潜能进行展望,为软组织再生力医学的发展提供新方向.
Abstract
Soft tissue and organ defects or degeneration,caused by trauma,disease,and aging,lead to a great burden on human health,and soft tissue regeneration technology has shown great promise for addressing these challenges.In recent years,interdisciplinary efforts in the fields of biomechanics,mechanobiology and regenerative medicine have highlighted the critical roles of mechanical cues in microenvironment in regulating soft tissue regeneration.Despite these advances,there is still a lack of comprehensive understanding regarding the mechanical features of soft tissues in clinical practice,and the full potential of such mechanical features for diagnosing and treating soft tissue diseases has not been fully known.In this review,the concept of'mechanomedicine for soft tissue regeneration'is proposed.Subsequently,the possible influence mechanisms of mechanical cues on soft tissue development and regeneration are systematically described from four distinct aspects,i.e.,multi-scale biomechanics of soft tissues,mechanobiology of soft tissue regeneration,mechanomedicine techniques for soft tissue regeneration,and applications of mechanomedicine for soft tissue regeneration.Finally,the potential of mechanomedicine in clinical diagnosis of soft tissue diseases and soft tissue defect repair is discussed,thereby providing a new direction for the development of mechanomedicine for soft tissue regeneration.
关键词
力医学/力学生物学/力治疗学/力学微环境/软组织再生Key words
mechanomedicine/mechanobiology/mechanotherapy/mechanical microenvironment/soft tissue regeneration引用本文复制引用
基金项目
国家自然科学基金(12225208)
国家自然科学基金(11972279)
出版年
2024
NETL
NSTL
万方数据