High intensity focused ultrasound focus localization based on passive beamforming imaging
By combining the treatment probe with the imaging probe,this paper explored a new strategy of locating focus based on the passive beamforming principle in high intensity focused ultrasound(HIFU).This new method was able to estimate the HIFU focus which is more accurate than the current geometric focus being used in clinical practice.An ultrasound propagation model with multilayer tissue structure was developed in k-Wave simulation,providing an ideal method to validate robustness of the passive beamforming algorithm under a variety of fat and muscle thicknesses.Further,a preliminary validation was carried out in phantom experiment to demonstrate effectiveness of the proposed method.The simulation results showed that focal points estimated by the passive beamforming method under different fat thickness and the geometric focuses deviated from the actual focuses in the axial distance by(0.54±0.15)mm and(4.76±0.95)mm,respectively.Similarly,the deviations for the estimated focuses and the geometric focus under different muscle thickness were(0.51±0.26)mm and(4.95±0.47)mm respectively.The phantom experiment also verified that the estimated focal location was closer to the actual damage location.In conclusion,this study validated the superiority of passive beamforming method for estimating HIFU focus,which could help push this new method forward towards clinical applications.
High intensity focused ultrasoundPassive beamforming imagingFocus positioningk-WaveMulti-layer tissue mode
万方数据
维普
