A relative motion model was used to numerically simulate the phenomenon of particle aggregation in shear thinning fluids.To understand the shear thinning effects on particle mechanical properties in microfluid-ics,the shear thinning matching was performed with viscoelastic and non-viscoelastic fluids.The research re-sults indicate that,shear thinning characteristics can significantly alter the mechanical properties of particles.In non-viscoelastic fluids,shear thinning can cause the aggregation position of particles to move towards the wall,and has an incentive effect on the aggregation speed of particles.In viscoelastic fluids,the occurrence of shear thinning will bring a decrease of the fluid elasticity,resulting in particle convergence from the center to the wall.