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Mathematical Modeling of Cell Polarity Establishment of Budding Yeast

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The budding yeast Saccharomyces cerevisiae is a powerful model system for studying the cell polarity establishment.The cell polarization process is regulated by signaling mol-ecules,which are initially distributed in the cytoplasm and then recruited to a proper location on the cell membrane in response to spatial cues or spontaneously.Polarization of these signaling molecules involves complex regulation,so the mathematical mod-els become a useful tool to investigate the mechanism behind the process.In this review,we discuss how mathematical modeling has shed light on different regulations in the cell polarization.We also propose future applications for the mathematical modeling of cell polarization and morphogenesis.

Budding yeastCdc42MorphogenesisSeptinMathematical models

Yue Liu、Jun Xie、Hay-Oak Park、Wing-Cheong Lo

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Department of Mathematics,City University of Hong Kong,Tat Chee Avenue,Kowloon,Hong Kong,China

Department of Molecular Genetics,The Ohio State University,Columbus,OH,USA

2024

应用数学与计算数学学报
上海大学

应用数学与计算数学学报

影响因子:0.165
ISSN:1006-6330
年,卷(期):2024.6(1)
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