According to the related literatures the advances in resveratrol (Res)research of grape ( Vitis L.) were reviewed involving the prevention and treatment effects on human disease and the roles in plant disease resistance of Res, the extraction and determination methods, the contents, the biosynthesis and modifications of Res in grapes, etc. And the future studies should focus on the disease resistance mechanisms of Res in grapes, genetic analysis and hereditary researchs of the high-Res content grape genotypes, and the enzymatic and molecular mechanisms of Res synthesis in critical period of grape berry developments.