Effect of Carbon Dioxide dot-matrix Laser combined with topical bovine alkaline fibroblast Growth Factor in the Treatment of sunken Acne Scars
Objective To explore the therapeutic effect of carbon dioxide(CO2)dot-matrix laser combined with topical recombinant bovine basophilic fibroblast growth factor(rb-bFGF)on sunken acne scars.Methods A total of 96 patients with sunken acne scars who received treatment at Anyang District Hospital in Puyang City from May 2021 to April 2022 were randomly divided into control group(n=48)and study group(n=48)using a random number table method.The control group was treated with CO2 dot-matrix laser combined with physiological saline,while the study group was treated with CO2 dot-matrix laser combined with rb-bFGF.The treatment efficacy,acne scar weight score,quality of life,and adverse reactions between two groups were compared.Results The effective rate of treatment in the study group(97.92%)was higher than that in the control group(83.33%),and the difference was statistically significant(P＜0.05);After treatment,the echelle d'evaluation clinique des cicatrices d'acne(ECCA)scores of the two groups were lower than before treatment,and the scores of the study group were lower than those of the control group,with statistical significance(P＜0.05);After treatment,the Chinese version of the Dermatological Quality of Life Index(DLQI)scores in the two groups were lower than before treatment,and the scores in the study group were lower than those in the control group,with statistical significance(P＜0.05);The incidence of adverse reactions in the study group(4.17%)was lower than that in the control group(18.75%),and the difference was statistically significant(P＜0.05).Conclusion The application of CO2 dot-matrix laser combined with rb-bFGF in the treatment of acne scars can improve clinical efficacy,improve acne scar symptoms,improve quality of life,and have high safety.
carbon dioxide dot-matrix lasertopical recombinant bovine basophilic fibroblast growth factorsunken acne scarsclinical efficacyquality of life
国家科技期刊平台
NSTL
万方数据
维普
