Clinical Observation of Amiodarone and Metoprolol on the Treatment of Rapid Arrhythmia
Objective To analyze the clinical efficacy of Amiodarone and Metoprolol on the treatment of rapid arrhythmia(RA).Methods A total of 92 RA patients treated from January 2021 to December 2022 in Kaifeng People's Hospital were chosen as research samples.According to the guidance of interval random method,they were equally divided into the control group(46 cases)and the experimental group(46 cases).The treatment of the control group was amiodarone alone,and the treatment of the experimental group was amiodarone combined with metoprolol.A comparative study was conducted on the total effective rate of the two groups of treatment,cardiac function indicators,endothelial function indicators,Minnesota Heart Failure Quality of Life Scale Score(MLFHQ),and adverse drug reactions before and after treatment.Results The total effective treatment rates in the test group(97.83%)were significantly higher than control group(84.78%),and the difference was statistically significant(P＜0.05);before treatment,MLHFQ scores between groups were not significantly different(P＞0.05);after treatment,MLHFQ scores for two groups were reduced,but the descent degrees in the test group were even higher than control group,and the difference was statistically significant(P＜0.05);before treatment,the cardiac function indicators between groups were not significantly different(P＞0.05);after treatment,the cardiac function indicators for two groups were improved;the cardiac output,left ventricular ejection fraction and stroke volume values in the test group were significantly higher than control group;the left ventricular end-systolic diameter and left ventricular end-diastolic diameter were significantly smaller than control group,and the difference was statistically significant(P＜0.05);before treatment,the endothelial function indicators between groups were not significantly different(P＞0.05);after treatment,the endothelin contents in the test group were significantly lower than control group;the nitric oxide contents were significantly higher than control group,and the difference was statistically significant(P＜0.05);The incidence of adverse reactions caused by drugs in the test group(6.25%)was lower than that in the control group(10.87%),and the difference was not statistically significant(P＞0.05).Conclusion Amiodarone combined with metoprolol is a high-quality clinical drug regimen for RA,with ideal efficacy and safety,and is worthy of application.
amiodaronerapid arrhythmiametoprololcardiac function
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NSTL
万方数据
维普
