首页|探讨完壁式乳突根治与Wullstein Ⅲ型鼓室成形术对中耳炎患者听阈及血清的影响研究

探讨完壁式乳突根治与Wullstein Ⅲ型鼓室成形术对中耳炎患者听阈及血清的影响研究

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目的 探讨完壁式乳突根治鼓室成形术与WullsteinⅢ型鼓室成形术对中耳炎患者听阈平均值及血清血小板活化因子(PAF)、透明质酸(HA)表达的影响。方法 选取 2020 年 4 月至 2021 年 5 月河南省扶沟县人民医院收治的104 例中耳炎患者,依据随机数字表法分为研究组(n=52)及对照组(n=52)。对照组采取WullsteinⅢ型鼓室成形术,研究组采用完壁式乳突根治鼓室成形术。统计两组临床疗效、手术前后听阈平均值[气导(AC)阈值及骨导(BC)阈值]、血清PAF、HA表达。结果 研究组治疗有效率(94。23%)高于对照组(80。77%);术后两组AC低于术前,且研究组低于对照组,差异有统计学意义(P<0。05);两组BC与术前及组间比较,差异无统计学意义(P>0。05)。术后两组血清PAF、HA表达水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0。05)。研究组并发症发生率低于对照组,研究组复发率低于对照组,差异有统计学意义(P<0。05)。结论 治疗中耳炎患者采取完壁式乳突根治鼓室成形术在恢复患者听力、提高治疗效果方面优于WullsteinⅢ型鼓室成形术,且能调节血清PAF、HA表达。
To Investigate the Effect of Radical Mastoidectomy and Wullstein Type Ⅲ Tympanoplasty on Hearing Threshold and Serum in Patients with Otitis Media
Objective To investigate the effect of radical mastoidectomy tympanoplasty and Wullstein type Ⅲ tympanoplasty on the average hearing threshold and the expression of serum platelet-activating factor(PAF)and hyaluronic acid(HA)in patients with otitis media.Methods A total of 104 patients with otitis media admitted to Fugou People's Hospital of Henan Province from April 2020 to May 2021 were selected and divided into the study group(n=52)and the control group(n=52)according to the random number table method.The control group was treated with Wullstein typeⅢ tympanoplasty,and the study group was treated with complete wall mastoid radical tympanoplasty.The clinical efficacy,the average hearing threshold[air conduction(AC)threshold and bone conduction(BC)threshold]before and after the operation,and the expression of serum PAF and HA were recorded.Results The effective rate of the study group(94.23%)was higher than that of the control group(80.77%).After the operation,AC was lower in the two groups than before the operation,and the study group was lower than the control group,the difference was statistically significant(P<0.05).There was no significant difference in BC between the two groups before and between the two groups(P>0.05).The expression levels of serum PAF and HA in the two groups were lower than before,and the study group was lower than the control group,the difference was statistically significant(P<0.05).The complication rate of the study group was lower than that of the control group,and the recurrence rate of the study group was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of otitis media patients,radical mastoid tympanoplasty with the complete wall is superior to Wullstein type Ⅲ tympanoplasty in restoring hearing and improving treatment effect and can regulate the expression of serum PAF and HA.

otitis mediacomplete mastoidectomy tympanoplastyWullstein type Ⅲ tympanoplasty

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扶沟县人民医院 耳鼻喉科,河南 周口 461300

中耳炎 完壁式乳突根治鼓室成形术 Wullstein Ⅲ型鼓室成形术

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(1)
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