To Explore the Curative Effect of Yiganling Combined with Diammonium Glycyrrhizinate on Anti-tuberculosis Drug-induced Liver Injury
Objective To investigate the efficacy of Yiganling combined with diammonium glycyrrhizinate in the treatment of anti-tuberculosis drug-induced liver injury(ATB-DILI),and to analyze its effects on liver function,inflammatory level and immunological functioning.Methods A total of 80 patients with ATB-DILI admitted to Luyi County Center for Disease Prevention and Control hospital from June 2021 to June 2023 were selected as the study objects and randomly divided into a single group of 40 cases and a combination group of 40 cases.The single group was treated with diammonium glycyrrhizinate,and the combined group was treated with Yiganling combined with diammonium glycyrrhizinate.Count and compare the clinical efficacy,adverse reactions,and clinical symptom scores of the two groups,as well as changes in liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),γ-glutamyl transpeptidyase(γ-GT)],inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)],and peripheral blood T lymphocyte subsets(CD3+,CD4+,CD8+)levels before and after treatment.Results The total effective rate of combined group was higher than that of single group,and the difference was statistically significant(P＜0.05);after treatment,the clinical symptom score of combination group was lower than that of single group,and the difference was statistically significant(P＜0.05);after treatment,the serum ALT,AST,TBIL,γ-GT,IL-6,TNF-α and IL-1β levels in combined group were lower than those in single group,and the differences were statistically significant(P＜0.05);after treatment,the CD3+ and CD4+ levels in the combined group were higher than those in the single group,while the CD8+ levels were lower than those in the single group,and the difference was statistically significant(P＜0.05);there was no significant difference in the incidence of adverse reactions between the combined group and the single group(P＞0.05).Conclusion Yiganling combined with diammonium glycyrrhizinate is effective and safe in the treatment of ATB-DILI,which can improve clinical symptoms,immune function,promote liver function recovery,and inhibit inflammatory reactions.
国家科技期刊平台
NSTL
万方数据
维普
