Predictive Value of Cardiac Failure Ultrasound Index Combined with Serum CA125 and BNP for MACE in Senile Diastolic Heart Failure
Objective To investigate the heart failure predictive value of ultrasound index(HFEI)combined with serum carbohydrate antigen 125(CA125)and B-type natriuretic peptide(BNP)for adverse cardiovascular events(MACE)in elderly patients with diastolic heart failure(DHF).Methods Seventy-eight elderly DHF patients admitted to Zhengzhou Yihe Hospital from March 2021 to March 2022 were selected.According to whether the patients developed MACE during the follow-up period,they were divided into patients without MACE(43 cases in the control group)and patients with MACE(35 cases in the observation group).The clinical data,HFEI[Left ventricular end-diastolic Diameter(LVEDd),left ventricular ejection fraction(LVEF),Peak early diastolic filling velocity/Peak end diastolic filling velocity(E/A)],serum CA125 and BNP levels of the control group and the observation group were compared.The influencing factors of MACE in elderly DHF patients were analyzed.The predictive efficacy of HFEI,serum CA125 and BNP for MACE was analyzed,and ROC curve was drawn.Results LVEDd,HFEI,CA125 and BNP in the observation group were higher than those in the control group(P＜0.05),while LVEF and E/A in the observation group were lower than those in the control group,the difference was statistically significant(P＜0.05).HFEI,CA125 and BNP were independent risk factors for MACE in elderly DHF patients,the difference was statistically significant(P＜0.05).The area under the curve(AUC)value of MACE predicted by HFEI,CA125 and BNP combined detection was higher than that by single detection,the difference was statistically significant(P＜0.05).Conclusion The value of heart failure ultrasound index combined with serum CA125 and BNP in predicting MACE in elderly DHF patients is higher.
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