To Observe the Therapeutic Effect of Montelukast Sodium Combined with Ambroxol Hydrochloride on Children with Bronchial Asthma
Objective To explore the effect of montelukast sodium and ambroxol hydrochloride on clinical efficacy,immune globulin and inflammatory factor levels in children with bronchial asthma(BA).Methods A total of 88 BA children who were treated in Luoyang Sixth People's Hospital from January 2020 to January 2022 were selected,and divided into study group(44 cases,montelukast sodium combined with ambroxol hydrochloride)and control group(44 cases,ambroxol hydrochloride alone)according to random number table method.The clinical efficacy,immune globulin and inflammatory factor levels were compared between the two groups.Results In the total effective rate of treatment,in comparision of the control group(81.82%),the study group(95.45%)was higher(P＜0.05).After treatment,the immunoglobulin A(IgA)levels in both groups were increased,the immunoglobulin E(IgE)and immunoglobulin M(IgM)levels were decreased(P＜0.05),and in comparision of the control group,IgA levels in the study group were higher(P＜0.05),and IgE and IgM levels were lower(P＜0.05).After treatment,the interferon-γ(INF-γ)levels inboth groups were increased,interleukin-8(IL-8)and interleukin-33(IL-33)levels were decreased,and in comparision of the control group,INF-γ levels in the study group were higher,and IL-8 and IL-33 levels were lower(P＜0.05).Conclusion Montelukast sodium combined with ambroxol hydrochloride therapy for children with BA can improve the clinical efficacy and improve the levels of immunoglobulin and inflammatory factors.
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