超早期小骨窗微创血肿清除术治疗高血压性脑出血的有效性及安全性
Effectiveness and Safety of minimally invasive Hematoma Removal Surgery with ultra-early small Bone Window in the Treatment of hypertensive intracerebral Hemorrhage
韩沛沛 1吴先珍1
作者信息
- 1. 虞城县人民医院 神经外科,河南 商丘 476300
- 折叠
摘要
目的 探讨高血压性脑出血(HICH)患者采用超早期小骨窗微创血肿清除术治疗的有效性及安全性.方法 选取 2021 年 6 月至 2022 年 9 月虞城县人民医院收治的 94 例HICH患者,以随机数字表法分成研究组(n=47,超早期小骨窗微创血肿清除术)与对照组(n=47,常规开颅血肿清除术),对两组临床疗效、神经功能、氧化应激指标及并发症发生率进行比较.结果 研究组治疗有效率(93.62%)高于对照组(78.72%),差异有统计学意义(P＜0.05);与术前相比,术后两组美国国立卫生研究院卒中量表(NIHSS)评分均降低,差异有统计学意义(P＜0.05);术后研究组NIHSS评分低于对照组,差异有统计学意义(P＜0.05);术后两组超氧化物歧化酶(SOD)水平较术前均提高,差异具有统计学意义(P＜0.05),丙二醛(MDA)、脂质过氧化物(LPO)、髓过氧化物酶(MPO)水平较术前均降低,差异具有统计学意义(P＜0.05);术后研究组SOD水平高于对照组,差异具有统计学意义(P＜0.05),MDA、LPO、MPO水平低于对照组,差异具有统计学意义(P＜0.05);研究组并发症发生率(8.51%)低于对照组(25.53%),差异具有统计学意义(P＜0.05).结论 超早期小骨窗微创血肿清除术用于治疗HICH,能够提高临床疗效,改善神经功能与氧化应激指标,降低并发症发生率.
Abstract
Objective To explore the effectiveness and safety of using ultra-early small bone window minimally invasive hematoma removal surgery for hypertensive intracerebral hemorrhage(HICH)patients.Methods A total of 94 HICH patients admitted to Yucheng County People's Hospital from June 2021 to September 2022 were selected and randomly divided into study group(n=47,minimally invasive hematoma removal surgery with ultra-early bone window)and control group(n=47,conventional craniotomy hematoma removal surgery)using a random number table method.The clinical efficacy,menstrual function,oxidative stress indicators,and incidence of complications were compared between the two groups.Results The effective rate of treatment in the study group(93.62%)was higher than that in the control group(78.72%),and the difference was statistically significant(P＜0.05);Compared with preoperative,the National Institutes of Health Stroke Scale(NIHSS)scores of both groups decreased after surgery,and the difference was statistically significant(P＜0.05);The postoperative NIHSS score in the study group was lower than that in the control group,and the difference was statistically significant(P＜0.05);After surgery,the levels of superoxide dismutase(SOD)in both groups increased compared to before surgery,and the difference was statistically significant(P＜0.05).The levels of malondialdehyde(MDA),lipid peroxide(LPO),and myeloperoxidase(MPO)decreased compared to before surgery,and the difference was statistically significant(P＜0.05);The SOD level in the postoperative study group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The MDA,LPO,and MPO levels were lower than those in the control group,and the difference was statistically significant(P＜0.05);The incidence of complications in the study group(8.51%)was lower than that in the control group(25.53%),and the difference was statistically significant(P＜0.05).Conclusion Minimally invasive hematoma removal surgery with ultra-early bone window for the treatment of HICH can improve clinical efficacy,improve neurological function and oxidative stress indicators,and reduce the incidence of complications.
关键词
高血压性脑出血/超早期小骨窗微创血肿清除术/有效性/安全性Key words
hypertensive intracerebral hemorrhage/minimally invasive hematoma removal surgery with ultra-early bone window/effectiveness/security引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据