Clinical Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Cognitive Dysfunction in Patients with Parkinson's Disease
Objective To explore the clinical effect of high-frequency repetitive transcranial magnetic stimulation in the treatment of cognitive dysfunction in patients with Parkinson's disease.Methods A total of 82 patients with cognitive dysfunction in Parkinson's disease were selected from January 2022 to May 2023 in our hospital.They were divided into control group and research group,each with 41 cases,according to the random number table method.The left dorsolateral prefrontal cortex was used as the stimulation area.The control group of 41 patients received sham stimulation treatment with high-frequency repetitive transcranial magnetic stimulation(25 Hz),and the research group of 41 patients received real stimulation treatment with high-frequency repetitive transcranial magnetic stimulation(25 Hz).The cognitive dysfunction level,P300 changes,and psychological level before and after clinical treatment of the two groups of patients were compared.Results There was no significant difference in the Montreal Cognitive Assessment(MoCA)score between the research group and the control group before treatment(P＞0.05).The MoCA score of the patients in the research group was higher than that of the control group after 1 month and 3 months of treatment,and the difference was statistically significant(P＜0.05).There was no significant difference in P300 amplitude and latency between the research group and the control group before treatment(P＞0.05).After treatment,the P300 amplitude of the research group significantly increased and the latency decreased,which was statistically significant compared with the control group(P＜0.05).There was no significant difference in the Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)scores between the two groups of patients before treatment(P＞0.05).After treatment,the HAMA and HAMD scores of the research group decreased compared with the control group,and the difference was statistically significant(P＜0.05).Conclusion High-frequency repetitive transcranial magnetic stimulation is an effective method for treating cognitive dysfunction in patients with Parkinson's disease.It can improve the cognitive function level of patients and improve the psychological level of patients by regulating the neural activity of specific brain areas.
Cognitive DysfunctionParkinson's DiseaseHigh-Frequency Repetitive Transcranial Magnetic Stimulation
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