Therapeutic Efficacy of Cefoperazone Sulbactam Combined with Inhaled Budesonide in Bacterial Pneumonia and the Effect on the Expression of Inflammatory Factors in Patients
Objective To investigate the effect of cefoperazone sulbactam combined with budesonide inhalation in the treatment of bacterial pneumonia.Methods A total of 82 patients with bacterial pneumonia treated at the Second People's Hospital of Zhengzhou City from December 2021 to June 2023 were selected and divided into 41 cases each in the control group(cefoperazone sulbactam)and the observation group(combined with budesonide inhalation)by applying the random number table method,and the two groups were compared in terms of clinical efficacy,time of symptomatic improvement,blood gas indexes(partial pressure of blood oxygen,oxygenation index,oxygen saturation),inflammatory factors[interleukin-10(IL-10),interleukin-6(IL-6),tumour necrosis factor(TNF-α),C-reactive protein(CRP)],and adverse reactions.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The time of fever,cough and disappearance of pulmonary rales in the observation group was shorter than that in the control group,the difference was statistically significant(P＜0.05).The partial pressure of blood oxygen,oxygenation index and oxygen saturation of the observation group were higher than that of the control group,the difference was statistically significant(P＜0.05).IL-6,TNF-α,CRP of the observation group were lower than that of the control group,and IL-10 was higher than that of the control group,the difference was statistically significant(P＜0.05).The difference in adverse reactions between the observation group and the control group was not statistically significant(P＞0.05).Conclusion Bacterial pneumonia in patient receiving cefoperazone sulbactam combined with budesonide inhalation therapy,improve the patients'blood gas indexes,and promote recovery,and it is safe.
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