Study on the Prevalence and related Factors of subclinical Hypothyroidism in Individuals with abnormal Lipid Metabolism
Objective To explore the prevalence and related factors of subclinical hypothyroidism(SCH)in individuals with abnormal lipid metabolism.Methods A total of 3650 individuals with abnormal lipid metabolism who were admitted to the Red Cross Hospital of Wuzhou City from January 2018 to December 2022 were selected to analyze the incidence of SCH.Clinical data of SHC patients and non-SCH patients were compared,and the differences were calculated using the logistic regression equation to analyze their impact on the incidence of SCH in the population with abnormal lipid metabolism.Results Among the population with abnormal lipid metabolism,there were 962 patients with SCH,with a prevalence rate of 26.36%;Univariate Logistic regression analysis showed that there were significant differences in sex,body mass index(BMI),triglyceride(TG),diastolic blood pressure(DP),antithyroglobulin antibody(TgAb),systolic blood pressure(SP),age,fasting blood glucose(FBG),low-density lipoprotein(LDL-C),2h post load plasma glucose(2hPG),total cholesterol(TC),high-density lipoprotein(HDL-C),aspartate transaminase(AST),serum calcium,phosphorus,uric acid(UA)and thyroid peroxidase antibody(TPOAb)between the SCH and non-SCH patients(P＜0.05).Different types of lipid metabolism abnormalities are mainly characterized by hypertriglyceridemia,with statistically significant differences(P＜0.05).The population with lipid metabolism abnormalities has the highest incidence of SCH mixed with hyperlipidemia,with statistically significant differences(P＜0.05);Multivariate logistic regression analysis was conducted on the influencing factors with differences in the above comparison,and it was found that gender,age,SP,TC,FBG,and 2hPG were all independent factors affecting the incidence of SCH in individuals with abnormal lipid metabolism.Conclusion There is a close relationship between abnormal lipid metabolism and the occurrence of SCH disease,which is more prominent in female and elderly patients.Blood lipids may affect the secretion of thyroid hormones to a certain extent,ultimately leading to SCH.Therefore,clinical attention should be paid to relevant factors and prevention and treatment should be carried out.
万方数据
维普
