Investigation and Study on the Distribution and Drug Resistance of pathogenic Bacteria in infectious Wounds of critical Burn Patients
Objective To analyze and study the distribution and drug resistance of pathogens causing wound infection in critically burn patients.Methods A total of 96 critically burned patients from Nanyang Central Hospital from January 2020 to January 2023 were selected as the research subjects.Secretions such as wounds,venous blood,pus,and sputum were collected from the patients,and the infection status and drug resistance changes of pathogens were analyzed.Results Among the 96 critically burned patients,76 were infected with pathogens,with an infection rate of 79.17%.A total of 215 strains of pathogenic bacteria were detected,mainly from wound secretions,accounting for 37.67%,followed by venous blood,pus,sputum,other fluids,and urine,accounting for 26.98%,12.56%,8.84%,7.44%,and 6.51%,respectively,and showing an increasing trend year by year,the detection rate increased from 23.26%to 45.12%;101 strains of gram-positive bacteria,of which 16.28%are staphylococcus aureus,of which MRSA accounts for 40.00%;There are a total of 91 gram-negative bacteria,with a detection rate of 14.42%for pseudomonas aeruginosa,followed by escherichia coli with a detection rate of 8.84%,and a total of 13 fungi with a detection rate of 6.05%;MRSA is sensitive to linezolid,teicoplanin,and vancomycin,and no resistant strains have emerged.However,the resistance rate to fluoroquinolones,rifampicin,and gentamicin antibiotics is less than 20%,and the resistance rate to erythromycin and clindamycin is 85.71%;Among gram negative bacteria,pseudomonas aeruginosa has the highest detection rate,with high resistance to cefazolin,cefuroxime,cefuroxime axetil,and cefotetan,while low resistance to aminoglycosides and quinolones;In escherichia coli,the resistance rate to ciprofloxacin and levofloxacin is high and is increasing year by year,with no tolerance to cefuroxime and cefuroxime axetil.Conclusion The pathogenic bacteria in critically burned patients are mainly staphylococcus aureus,pseudomonas aeruginosa,and escherichia coli,with multiple drug uses.Therefore,regular monitoring of pathogen distribution and drug resistance migration can effectively control the development of drug-resistant bacteria.
万方数据
维普
