Comparison of Short-term Efficacy and Prognosis of Transnasal Sphenoidal Approach Resection of Pituitary Tumors by Neuroendoscopy and Microscope
Objective To investigate the short-term effect and prognosis of transnasal sphenoidal approach resection of pituitary tumor by neuroendoscopy and microscope.Methods A total of seventy-eight patients with pituitary tumors admitted to zhoukou orthopaedic hospital October 2020 to October 2021 were randomly divided into the study group(39 patients with pituitary tumors removed by endoscopic transnasal transsphenoidal approach)and the control group(39 patients with pituitary tumors removed by endoscopic transnasal transsphenoidal approach)according to the digital table method.The curative effect,surgical related indexes,olfactory function,visual function and hormone level before and after treatment were compared between the two groups;The complication rate,one-year postoperative recurrence rate and quality of life score of the two groups were compared.Results The total effective rate of the study group(94.87%)was higher than that of the control group(76.92%),the difference is statistically significant(P＜0.05);The operation time,intraoperative bleeding and postoperative hospital stay in the study group were lower than those in the control group,the difference is statistically significant(P＜0.05);One month after operation,the olfactory recognition threshold in the two groups were higher than those before operation,and those in the control group were higher than those in the study group,the difference is statistically significant(P＜0.05);One month after surgery,the average visual field defect in both groups was lower than before surgery,and the study group was lower than the control group,with a statistically significant difference(P＜0.05);One month after surgery,the weighted visual field index of both groups was higher than before surgery,and the study group was higher than the control group,with a statistically significant difference(P＜0.05);One month after surgery,the levels of prolactin,growth hormone,and adrenocorticotropic hormone in both groups were lower than before surgery,and the study group was lower than the control group,with statistically significant differences(P＜0.05).The incidence of complications in the study group(10.26%)was lower than that in the control group(30.77%),and the difference was statistically significant(P＜0.05).The one-year recurrence rate of the study group(5.13%)was lower than that of the control group(25.64%),and the difference was statistically significant(P＜0.05);The quality of life in the two groups after 1 year was higher than that before operation,and that in the study group was higher than that in the control group,the difference is statistically significant(P＜0.05).Conclusion Neuroendoscopic transnasal transsphenoidal approach for pituitary tumor resection has better curative effect than microscope,lower complication rate and recurrence rate,and can improve patients'sense of smell,visual function,hormone and quality of life.
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