Logistic Multivariate Regression Analysis of the Relationship between perinatal Outcomes and related Factors during early Pregnancy in Women with gestational Diabetes Mellitus
Objective To explore the relationship between the increase of body mass index(BMI)in early pregnancy,the time of glucose in the target range within 24 hours and perinatal outcomes in patients with gestational diabetes mellitus(GDM).Methods From October 2019 to October 2021,a total of 188 patients with GDM who were admitted to the General Hospital of Jinshui District,Zhengzhou City,were retrospectively analyzed.All the subjects received regular monitoring of BMI and blood glucose levels in the early stage of pregnancy;Patients'medical records were consulted and all subjects were divided into two groups according to perinatal outcomes:smooth pregnancy group(n=123)and adverse outcome group(n=65);General information of patients was collected,and BMI increase,fasting blood glucose(FBG),glucose in the target range within 24 hours,and glycated hemoglobin(HbA1c)were recorded during early pregnancy.Single factor Logistic regression analysis was used to explore the related factors that might affect the perinatal outcomes of GDM patients,and then the factors with statistical significance between groups were included in the Logistic multivariate analysis to explore the independent risk factors of adverse perinatal outcomes in patients with GDM.Results The results of univariate regression analysis showed that the proportion of cases with pregnancy complicated hypertension and GDM family history in the adverse outcome group was higher than that in the smooth pregnancy group,and the difference was statistically significant(P＜0.05);In addition,the maternal blood lactate,early pregnancy BMI index increase,FBG,and HbA1c levels in the adverse outcome group were significantly higher than those in the smooth pregnancy group,and the glucose within the target range was lower than that in the smooth pregnancy group,the difference was statistically significant(P＜0.05);The results of multiple regression analysis showed that high increase in BMI during early pregnancy,high levels of FBG and HbA1c in pregnant women,and low duration of glucose within the target range were independent risk factors for adverse perinatal outcomes in GDM mothers(P＜0.05).Conclusion There is a significant correlation between early pregnancy BMI increase and glucose levels in GDM patients and perinatal outcomes within the target time range.High BMI increase,low glucose within the target time range,high fasting blood glucose and glycated hemoglobin are independent risk factors for adverse perinatal outcomes in GDM women.
gestational diabetes mellitusearly pregnancybody mass indexglucose levelsperinatal outcome
万方数据
维普
