Effects of Dexmedetomidine on the Depth of Anesthesia During Target-controlled Infusion of Propofol Combined with Sufentanil
Objective To explore the effect of dexmedetomidine(DEX)on the depth of anesthesia during target-controlled infusion of propofol combined with sufentanil.Methods A total of 90 patients undergoing subtotal thyroidectomy at the Zhengzhou Third People's Hospital from August 2021 to July 2022 were selected,all of whom received target-controlled infusion of propofol combined with sufentanil anesthesia.they were divided into study group(n=45)and control group(n=45)by random number table method.The study group received intravenous infusion of DEX diluted drug and physiological saline,while the control group received intravenous infusion of physiological saline(at the same dose).The changes of entropy index(EI)of two groups(after induction,during operation,and after surgery)were observed,and the mean arterial pressure(MAP),heart rate(HR),observer's assessment alert/sedation score(OAA/S)before administration(T0),5 min(T1),10 min(T2),and 20 min(T3)of the two groups were recorded,and the recovery time of anesthesia was counted.Results The reaction entropy(RE)and state entropy(SE)of the two groups decreased at induction,operation and after operation,the difference was statistically significant(P＜0.05),but in comparision of the control group,the study group was higher,the difference was statistically significant(P＜0.05).MAP at T1,T2 in both groups were increased,the difference was statistically significant(P＜0.05),HR at T1,T2,T3 were decreased,the difference was statistically significant(P＜0.05),OAA/S scores at T1,T2,T3 were decreased,the difference was statistically significant(P＜0.05),in comparision of the control group,MAP at T1,T2 in the study group was higher,the difference was statistically significant(P＜0.05),HR at T2,T3 in the study group was lower,the difference was statistically significant(P＜0.05),and OAA/S at T2,T3 scores in the study group were higher,the difference was statistically significant(P＜0.05).In comparision of the control group,in the breathing and eye opening and extubation time,the study group were shorter,the difference was statistically significant(P＜0.05).Conclusion The application of DEX in target-controlled infusion of propofol combined with sufentanil during anesthesia can improve the quality of anesthesia,keep the hemodynamics in a stable state,have a significant sedative effect,and shorten the recovery time of anesthesia.
dexmedetomidinepropofolsufentaniltarget-controlled infusiondepth of anesthesia
万方数据
维普
