Observation on the therapeutic Effect of Cefoperazone Sulbactam combined with Azithromycin in the Treatment of Lobar Pneumonia in Children
Objective To explore the therapeutic effect of cefoperazone sulbactam combined with azithromycin in the treatment of pediatric lobar pneumonia.Methods A total of 62 pediatric patients with lobar pneumonia were selected from Luoyang Central Hospital from January 2021 to July 2023.They were randomly divided into control group and observation group using a random number table method,with 31 cases in each group.The control group was treated with azithromycin,while the observation group was treated with cefoperazone sulbactam in addition to the control group.The treatment efficacy,duration of clinical symptoms,levels of inflammatory response factors and T lymphocytes,and incidence of adverse reactions between two groups were compared.Results The effectiveness rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05);The cough disappearance time,fever reduction time,lung rale disappearance time,and hospitalization time of the observation group were all shorter than those of the control group,and the differences were statistically significant(P＜0.05);After treatment,The level C-reactive protein(CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).The levels of CD3+and CD4+were higher than those in the control group,while CD8+was lower,and the difference was statistically significant(P＜0.05);There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of cefoperazone sulbactam and azithromycin has a significant therapeutic effect on pediatric lobar pneumonia,which can effectively improve clinical symptoms and inflammatory reactions,enhance immune function,and is safe and reliable.
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