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间苯三酚治疗先兆流产的临床应用疗效分析

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目的 研讨间苯三酚治疗先兆流产的临床应用疗效。方法 选择洛阳市中医院 2022 年 2 月至 2023 年 2 月收治的先兆流产患者 72 例,按随机数字表法分成对照组和观察组,各 36 例。对照组给予地屈孕酮治疗,观察组在对照组基础上加用间苯三酚,比较两组治疗有效率、保胎成功率、症状消失时间、血清指标及不良反应发生率。结果 观察组治疗有效率(94。44%)显著高于对照组(77。78%),保胎成功率(88。89%)显著高于对照组(69。44%),宫缩消失时间及下腹部疼痛、阴道出血消失时间均显著短于对照组,差异有统计学意义(P<0。05)。治疗前,两组孕激素(P)、β亚单位人绒毛膜促性腺素(β-HCG)、雌二醇(E2)值比较,差异无统计学意义(P>0。05);治疗后,两组P、β-HCG、E2 值均高于治疗前,但两组P、β-HCG值比较,差异无统计学意义(P>0。05),而观察组E2 值显著高于对照组,差异有统计学意义(P<0。05)。观察组用药不良反应发生率为 8。33%,对照组为 2。78%,差异无统计学意义(P>0。05)。结论 间苯三酚治疗先兆流产治疗有效率和保胎成功率更高,不仅能缩短宫缩及下腹部疼痛、阴道出血等症状消失时间,还能改善E2 水平,用药安全性高,值得临床应用。
Clinical Effect of Phloroglucinol in the Treatment of threatened Miscarriage
Objective To explore the clinical efficacy of phloroglucinol in the treatment of threatened miscarriage.Methods A total of 72 patients with threatened miscarriage admitted to Luoyang Traditional Chinese Medicine Hospital from February 2022 to February 2023 were divided into control group and observation group according to the random number table,with 36 cases in each group.The control group received treatment with dexamethasone,while the observation group received additional treatment with phloroglucinol on the basis of the control group.The effective rate of treatment,success rate of fetal protection,time of symptom disappearance,serum indicators,and incidence of adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group(94.44%)was significantly higher than that in the control group(77.78%),and the success rate of fetal preservation(88.89%)was significantly higher than that in the control group(69.44%),the disappearance time of uterine contractions,lower abdominal pain,and vaginal bleeding were significantly shorter than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of progesterone(P),β human chorionic gonadotropin(β-HCG)and estradiol(E2)between the two groups(P>0.05);The levels of P,β-HCG and E2 in two groups after treatment were all higher than those before treatment,but there was no significant difference between two groups in the levels of P,β-HCG(P>0.05),while the E2 value in the observation group was significantly higher than that in the control group,with a statistically significant difference(P<0.05).The incidence of adverse drug reactions in the observation group was 8.33%,while in the control group it was 2.78%,with no statistically significant difference(P>0.05).Conclusion The treatment of threatened miscarriage with phloroglucinol has a higher effective rate and success rate in protecting the fetus.It can not only shorten the time for symptoms such as uterine contractions,lower abdominal pain,and vaginal bleeding to disappear,but also improve E2 levels.The medication is safe and worthy of clinical application.

threatened miscarriagephloroglucinolsuccess rate of preventing pregnancyeffective rate of treatment

秦艳华

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洛阳市中医院 妇产科,河南 洛阳 471000

先兆流产 间苯三酚 保胎成功率 治疗有效率

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(3)
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