Efficacy and Safety of low-dose Insulin combined with Somatostatin in Patients with Diabetes Ketoacidosis
Objective To explore the therapeutic effect of low-dose insulin combined with somatostatin on diabetes ketoacidosis.Methods From December 2020 to December 2022,94 patients with diabetes ketoacidosis admitted to the Fifth Affiliated Hospital of Zhengzhou University were randomly divided into control group(low-dose insulin)and observation group(combined somatostatin)with 47 cases each.The treatment efficiency,the improvement time of clinical indicators,blood sugar,blood potassium,blood sodium,serum amylase,ketone body,triglycerides,inflammatory factors,stress state and the incidence of adverse reactions of the two groups were compared.Results The improvement time of clinical symptoms in the observation group was shorter than that in the control group,and the difference was statistically significant(P＜0.05).The observation group had lower blood glucose and sodium levels than the control group,and higher blood potassium levels than that in the control group,with statistically significant differences(P＜0.05).The levels of serum amylase,ketone bodies,and triglycerides in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The levels of interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor α(TNF-α)in the observation group were significantly lower than those in the control group,the difference was statistically significant(P＜0.05);The levels of total antioxidant capacity(TAC),catalase(CAT),and glutathione peroxidase(GSH-Px)in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of adverse reactions in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Low-dose insulin combined with somatostatin in the treatment of diabetes ketoacidosis can rapidly improve the clinical symptoms,control the blood sugar level,reduce the inflammatory level,and enhance the antioxidant capacity of the body.
万方数据
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