Analysis of the Effect of Anti-Sense Granules Combined with Ribavirin in the Treatment of Children with Hand,Foot,and Mouth Disease
Objective To analyze the efficacy of anti-sense granules + ribavirin on hand,foot,and mouth disease(HFMD)in children and its impact on the patient's immune function and inflammatory factors.Methods 76 children with HFMD admitted to Nanyang City Central Hospital from January 2021 to January 2023 were selected as the research subjects.According to the interval random method,they were divided into a control group and a research group,each with 38 cases.The control group was treated with ribavirin alone,and the research group was treated with anti-sense granules + ribavirin.Compare the effective rate of the two groups,the disappearance time of basic symptoms,the inflammatory factor indicators before and after treatment[C-reactive protein(CRP),procalcitonin(PCT),interleukin 6(IL-6),tumor necrosis factor α(TNF-α)]and immune function indicators[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)].Results The effective rate of the research group was significantly higher than that of the control group.The recovery time of herpes,body temperature,oral ulcers,and appetite in the research group were significantly shorter than those in the control group;before treatment,the comparison of various inflammatory factor levels between the two groups showed no statistical significance(P＞0.05).After treatment,the levels of CRP,PCT,TNF-α,and IL-6 in both groups were significantly lower than before treatment,and the research group was significantly lower than the control group,with statistically significant differences(P＜0.05);before treatment,the comparison of various immune function indicators between the two groups showed no statistical significance(P＞0.05).After treatment,the levels of IgA,IgG,and IgM in both groups were significantly increased,and the research group was significantly higher than the control group,with statistically significant differences(P＜0.05).Conclusion Compared with single ribavirin treatment,the combined treatment of anti-sense granules + ribavirin for HFMD is more ideal,can enhance the immune function of the children,reduce the level of body inflammatory factors,and is worth applying.
Anti-sense granulesRibavirinHand,foot,and mouth disease in childrenImmune functionInflammatory factors
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维普
