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补肾骨痛汤在维持性血液透析患者骨痛治疗效果

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目的 分析补肾骨痛汤在维持性血液透析患者骨痛治疗效果。方法 将濮阳市清丰县中医院 2021 年 1 月至2023年3月维持性血液透析合并骨痛的患者(72例)作为研究对象,依据区间随机法将其分为对照组与研究组,各36例,对照组行常规西药治疗,研究组应用常规西药治疗的基础下增加补肾骨痛汤行中医辩证治疗。比较两组治疗前后骨痛程度、骨矿代谢相关指标、肾功能指标变化情况及用药期间不良反应发生情况。结果 治疗前两组骨痛程度评分对比差异无统计学意义(P>0。05),治疗第 2 月、第 4 月、第 6 月两组骨痛程度评分均与治疗前明显降低,且研究组评分低于对照组,差异有统计学意义(P<0。05);治疗前两组骨矿代谢相关指标对比差异无统计学意义(P>0。05),治疗后研究组血钙高于对照组,血磷、全段甲状旁腺激素、血清骨特异性碱性磷酸酶低于对照组,差异有统计学意义(P<0。05);治疗前两组血尿素氮、血清肌酐、肾小球滤过率水平对比差异无统计学意义(P>0。05),治疗后研究组尿素氮、血肌酐与对照组相比更低,肾小球滤过率更高,差异有统计学意义(P<0。05);对照组、研究组用药期间不良反应发生率分别为11。11%、16。67%,差异无统计学意义(P>0。05)。结论 补肾骨痛汤具有滋补肝肾,祛风除湿,活血通络的功效,可缓解维持性血液透析患者骨痛,值得应用。
The therapeutic Effect of Bushen Gutong Decoction on Bone Pain in maintenance Hemodialysis Patients
Objective To analyze the therapeutic effect of Bushen Gutong decoction on bone pain in maintenance hemodialysis patients.Methods A total of 72 patients with bone pain during maintenance hemodialysis at Qingfeng County Traditional Chinese Medicine Hospital in Puyang City from January 2021 to March 2023 were selected as the study subjects.They were randomly divided into control group and study group using interval randomization method,with 36 patients in each group.The control group received conventional Western medicine treatment,while the study group received traditional Chinese medicine dialectical treatment with Bushen Gutong decoction in addition to conventional Western medicine treatment.The degree of bone pain,bone mineral metabolism related indicators,changes in renal function indicators,and incidence of adverse reactions during medication between two groups before and after treatment were compared.Results There was no statistically significant difference in bone pain scores between the two groups before treatment(P>0.05).At the second,fourth,and sixth months of treatment,the bone pain scores of the two groups were significantly reduced compared to those before treatment,and the scores of the study group were lower than those of the control group,with a statistically significant difference(P<0.05);There was no statistically significant difference in bone mineral metabolism related indicators between the two groups before treatment(P>0.05).After treatment,the blood calcium in the study group was higher than that in the control group,while blood phosphorus,whole parathyroid hormone,and serum bone specific alkaline phosphatase were lower than those in the control group,and the difference was statistically significant(P<0.05);There was no statistically significant difference in the levels of blood urea nitrogen,serum creatinine,and glomerular filtration rate between the two groups before treatment(P>0.05).After treatment,the study group had lower levels of urea nitrogen,serum creatinine,and glomerular filtration rate compared to the control group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions during medication in the control group and the study group were 11.11%and 16.67%,respectively,with no statistically significant difference(P>0.05).Conclusion Bushen Gutong decoction has the effects of nourishing the liver and kidney,dispelling wind and dampness,promoting blood circulation and unblocking collaterals,and can alleviate bone pain in maintenance hemodialysis patients.It is worth applying.

maintenance hemodialysisbone paintraditional Chinese medicine dialectics and treatmentBushen Gutong decoction

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濮阳市清丰县中医院 肾病科,河南 濮阳 457000

维持性血液透析 骨痛 中医辩证与治疗 补肾骨痛汤

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(4)
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