The Improvement Effect of Butylphthalide Combined with Ginkgo Biloba Injection Treatment on Neurological Function,Hemorheology and Inflammatory in ACI Patients
Objective To analyze the improvement effect of butylphthalide combined with ginkgo biloba injection treatment on neurological function,hemorheology and inflammatory in patients with acute cerebral infarction(ACI).Methods A total of 110 ACI patients admitted to Wuzhi County Hospital of Traditional Chinese Medicine from April 2021 to April 2023 were randomly divided into a control group and an observation group,with 55 cases in each group,using a random number table method.Both groups were treated for 14 days,and the neurological function,nerve injury,inflammatory factor levels,and hemodynamic indicators of the two groups were compared before and after 14 days of treatment;and the occurrence of adverse reactions in the two groups was counted and compared.The incidence of adverse reactions in the two groups was also compared.Results After 14 days of treatment,the National Institutes of Health Stroke Scale(NIHSS)scores of the two groups were lower than those before treatment,while the NIHSS scores of the observation group were lower than those of the control group,with a statistically significant difference(P＜0.05).After 14 days of treatment,the levels of neuron-specific enolase(NSE)were lower than those before treatment,while the levels of brain-derived neurotrophic factor(BDNF)and nerve growth factor(NGF)were higher than those before treatment in both groups.The NSE levels in the observation group were lower than those in the control group,while NGF and BDNF levels were higher than those in the control group,with a statistically significant difference(P＜0.05).After 14 days of treatment,the whole blood high shear viscosity,whole blood low shear viscosity,and plasma viscosity in the observation group were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P＜0.05).After 14 days of treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor(TNF-α)in the two groups were lower than those before treatment,and the observation group was lower than the control group,with a statistically significant difference(P＜0.05).The total incidence of adverse reactions in the observation group(10.91%)was lower than that in the control group(14.55%),but there was no statistically significant difference between the two groups(P＞0.05).Conclusion Treatment with butylphthalide combined with ginkgo biloba injection can effectively promote the recovery of neurological function,reduce inflammatory response and nerve damage,and improve patient hemorheology in ACI patients without significantly increasing the risk of adverse reactions.
万方数据
维普
