Relationship and diagnostic Efficacy between 4s-100 β Protein,Thyroid Function and cognitive Function in Schizophrenia
Objective To analyze the relationship and diagnostic efficacy between central nervous system specific proteins(S-100β),thyroid function and cognitive function in schizophrenia.Methods A total of 142 patients with schizophrenia were selected from the Second People's Hospital of Zhumadian City from May 2020 to December 2022,all of whom underwent continuous treatment for 6 weeks.According to the Mini Mental State Evaluation Scale(MMSE),they were divided into four subgroups:normal cognitive function(25～30 points,n=77 cases),mild cognitive impairment(21～24 points,n=41 cases),moderate cognitive impairment(14～20 points,n=15 cases),and severe cognitive impairment(≤13 points,n=9 cases).The levels of S-100β protein and five items of thyroid function[total thyroxine(TT4),total triiodothyronine(TT3),free thyroxine(FT4),free triiodothyronine(FT3),thyroid stimulating hormone(TSH),free triiodothyronine(FT3)]in patients with schizophrenia were compared before and after treatment,the levels of S-100β protein and five items of thyroid function in patients with different degrees of cognitive impairment were compared,and the correlation between the levels of S-100β protein and five items of thyroid function and MMSE score was analyzed,as well as the diagnostic value for schizophrenia.Results Compared with pre-treatment,After treatment the levels of serum S-100β protein,TT4,and FT4 decreased,while the levels of TT3,FT3,and TSH increased,with statistical significance(P＜0.05).Serum S-100β protein,TT4,and FT4 showed an increasing trend in patients with normal cognitive function,mild,moderate,and severe cognitive impairment,while FT3,TT3,and TSH showed a decreasing trend,with statistically significant differences(P＜0.05).Before treatment,there is a negative correlation between serum S-100β protein,TT4,FT4,and MMSE score,while TT3,FT3,TSH are positively correlated with MMSE score,and the difference is statistically significant(P＜0.05).The area under the curve(AUC)of the ROC curve for the combined diagnosis of S-100β protein and thyroid function in patients with schizophrenia reached 0.823,which is larger than the diagnosis of a single serum indicator,and the difference is statistically significant(P＜0.05).Conclusion S-100β protein and thyroid function are closely related to cognitive dysfunction in schizophrenia,and can serve as effective biological markers for the diagnosis and efficacy testing of schizophrenia.
schizophreniafive aspects of thyroid functionS-100β proteincognitive function
万方数据
维普
