Diagnostic Value of Fine-Needle Aspiration Cytology Combined with BRAFV600E Gene Testing in Thyroid Cancer
Objective To explore the diagnostic value of fine-needle aspiration cytology(FNAC)combined with brafV600E gene testing in thyroid cancer.Methods A total of 81 patients with suspected thyroid cancer who were admitted to the Third People's Hospital of Henan Province from January 2021 to December 2022 were selected.All patients underwent FNAC and brafV600E gene testing.Postoperative pathology served as the gold standard for comparison of the diagnostic value of FNAC,brafV600E gene testing,and their combination.Results Among the 81 patients with thyroid nodules,there were 36 cases of papillary thyroid carcinoma and 45 cases of benign nodules.The detection rates of positive and negative results in the combined examination were higher than those of brafV600E gene testing and FNAC alone,with statistically significant differences(P＜0.05).The positive predictive value and negative predictive value of the combined examination were higher than those of brafV600E gene testing and FNAC alone,with statistically significant differences(P＜0.05).The sensitivity of FNAC,brafV600E gene testing,and combined examination for diagnosing thyroid cancer were 58.33%,69.44%,and 97.22%,respectively.The specificity were 91.11%,91.11%,and 100.00%,respectively.The accuracy rates were 81.48%,76.54%,and 98.77%,respectively.The sensitivity and accuracy of the combined examination for diagnosing thyroid cancer were higher than those of single tests,with statistically significant differences(P＜0.05).Conclusion The diagnostic value of FNAC combined with brafV600E gene testing in thyroid cancer is high and worthy of reference.
thyroid cancerpositive predictive valuenegative predictive value
国家科技期刊平台
NSTL
万方数据
