Sensitivity and Specificity Analysis of Electrochemiluminescence Immunoassay Technology for Hashimoto's Thyroiditis
Objective To explore the sensitivity and specificity of Electrochemiluminescence Immunoassay(ECLIA)in patients with Hashimoto's thyroiditis(HT).Methods A total of 68 suspected HT patients who were examined at the Second Affiliated Hospital of Xinxiang Medical College in Henan from August 2020 to August 2022 were selected.All patients underwent ECLIA and Radioimmunoassay(RIA)tests,with symptoms,pathological examination,and follow-up results as the gold standard.The test results,positive rates,diagnostic value,and test time of different testing techniques were compared.Results The levels of Free Thyroxine(FT4),Free Triiodothyronine(FT3),Thyroid Peroxidase Antibody(TPOAb),Thyroid Stimulating Hormone(TSH),Thyroglobulin Antibody(TgAb),and Thyroid Stimulating Hormone Receptor Antibody(TRAb)measured by ECLIA were higher than those by RIA,and the differences were statistically significant(P＜0.05);The positive rates of FT3,FT4,TSH,TPOAb,TgAb,and TRAb measured by ECLIA were higher than those by RIA,and the differences were statistically significant(P＜0.05);The sensitivity,specificity,positive predictive value,negative predictive value,accuracy,and area under the curve(AUC)of ECLIA diagnosis were 95.83%,95.00%,97.87%,90.48%,95.59%,and 0.861,respectively,while those of RIA were 79.17%,60.00%,82.61%,54.54%,73.53%,and 0.753,respectively.ECLIA was higher than RIA,and the differences were statistically significant(P＜0.05);The average test time of ECLIA was shorter than that of RIA,and the difference was statistically significant(P＜0.05).Conclusion ECLIA has higher sensitivity and specificity in HT patients and can shorten the test time.
国家科技期刊平台
NSTL
万方数据
维普
