The Clinical Effect of Urapidil Injection on Enhancing Blood Pressure Reduction in Patients with Hypertensive Cerebral Hemorrhage
Objective To investigate the clinical effect of Urapidil injection on enhancing blood pressure reduction in patients with hypertensive cerebral hemorrhage.Methods A total of 82 hypertensive intracerebral hemorrhage patients who were admitted to Sui County People's Hospital for treatment from January 2020 to December 2021 were selected as the study subjects.All enrolled patients were randomly divided into two groups using a random number table:a control group of 41 cases and an observation group of 41 cases.On the basis of the conventional disposal plan,the control group adopted the conventional treatment method of urapidil.On the basis of the conventional disposal plan,the observation group adopted the enhanced blood pressure reduction treatment method of Uladipine.Compare the volume of cerebral hematoma,National Institutes of Health Neurological Deficiency Scale(NIHSS),changes in serum inflammatory factors,and changes in serum oxidative stress indicators between two groups of patients before and after treatment.Compare the changes in hemorheological indicators between two groups of patients before and after treatment.Compare the incidence of complications between two groups.Results After 14 days of treatment,the volume of cerebral hematoma,NIHSS score,high-sensitivity C-reactive protein(hs-CRP),Tumor necrosis factor-α(TNF-α),Malondialdehyde(MDA),whole blood high shear viscosity,plasma viscosity,whole blood low shear viscosity and fibrinogen(FIB)in the control group and observation group were significantly lower than those before treatment,the levels of superoxide dismutase(SOD)in control group and observation group were significantly higher than those before treatment,and the differences were statistically significant(P＜0.05),the volume of cerebral hematoma,NIHSS score,hs-CRP,TNF-α,MDA,whole blood high shear viscosity,plasma viscosity,whole blood low shear viscosity and FIB in the observation group were significantly lower than those in the control group,the SOD level in the observation group was significantly higher than that in the control group,and the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of complications during the medication process between the two groups(P＞0.05).Conclusion Compared with conventional intervention strategies,intensive antihypertensive therapy with Ula dil can significantly reduce the formation of intracranial hematoma and improve its protective effect on the brain,at the same time can also reduce the degree of oxidative stress,inflammatory reaction,thereby promoting blood circulation in the brain.
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维普
