Effect of Flurbiprofen Axetil on Perioperative Body Temperature and Chills in Patients Undergoing Radical Gastrectomy
Objective This study aimed to investigate the effects of flurbiprofen axetil on perioperative body temperature and chills in patients undergoing radical gastrectomy.Methods A total of 120 patients undergoing radical gastrectomy surgery from January 2020 to December 2021 were selected.They were randomly divided into two groups:a control group(n=55)and an observation group(n=56).After anesthesia induction,the control group received 10 mL of 0.9%physiological saline intravenously,while the observation group received 100 mg of flurbiprofen ester intravenously.Various parameters,including anesthetic drug dosage,surgery-related time,arterial pressure,heart rate,eardrum temperature,incidence and severity of chills,pain severity[visual analogue scale,(VAS)],and adverse reactions were compared between the two groups.Results There were no significant differences in sufentanil consumption,remifentanil consumption,anesthesia time,operation time,or postoperative extubation time between the two groups(P＞0.05).Additionally,there were no significant differences in mean arterial pressure,heart rate,or eardrum temperature at T1,T2,and T3 time points between the two groups(P＞0.05).The incidence and severity of chills in the recovery room were lower in the observation group than in the control group,with statistically significant differences(P＜0.05).However,there was no significant difference in the duration of chills between the two groups(P＞0.05).Pain severity in the observation group was significantly lower than in the control group at 0.5 and 1.2 hours after extubation(P＜0.05).There was no significant difference in the incidence of nausea and vomiting between the two groups at 1 hour after extubation(P＞0.05).Conclusion Intravenous infusion of 100 mg flurbiprofen axetil after anesthesia induction in patients undergoing radical gastrectomy can significantly reduce the incidence and severity of postoperative chills and alleviate postoperative pain without adverse effects on the circulatory system or additional adverse reactions.
国家科技期刊平台
NSTL
万方数据
维普
