Effect Analysis of Spleen Polypeptide Combined with Acetylcysteine in Treatment of Elderly Patients with Severe Pulmonary Infection
Objective To investigate the therapeutic effect of spleen polypeptide combined with acetylcysteine on elderly patients with severe pulmonary infection.Methods A total of 86 elderly patients with severe pulmonary infection admitted to Suixian People's Hospital from January 2021 to December 2023 were selected as study subjects and divided into control group(n=43)and observation group(n=43)according to a random number table.Both groups received conventional treatment,the control group was given atomized acetyl cysteine inhalation on this basis,and the observation group was given atomized acetyl cysteine inhalation combined with spleen polypeptide injection.The relevant clinical indicators of the two groups were compared before and after treatment:pulmonary function indicators(arterial partial pressure of oxygen,arterial partial pressure of carbon dioxide,oxygenation index),respiratory dynamic parameters(airway resistance,peak inspiratory pressure,mean airway pressure),serum stress indicators(serum free cortisol,adrenocorticotropin).Symptom duration,mechanical ventilation time,therapeutic effect and severe adverse reactions were compared between the two groups.Results After treatment,the partial blood oxygen pressure,oxygenation index and peak inspiratory pressure in observation group were higher than those in control group,while the partial blood carbon dioxide pressure,airway resistance,mean airway pressure,serum free cortisol and adrenocorticotropic hormone in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).The duration of fever,cough,tachypnea and mechanical ventilation in observation group were shorter than those in control group,and the differences were statistically significant(P＜0.05).The treatment effect grading of the observation group was better than that of control group,and the difference was statistically significant(P＜0.05).There were no serious adverse reactions in both groups.Conclusion For elderly patients with severe pulmonary infection,on the basis of conventional treatment,the combination of spleen polypeptide intravenous infusion and acetyl cysteine aerosol inhalation can effectively improve the therapeutic effect and clinical indicators of multiple dimensions,shorten the maintenance time of clinical symptoms and the use of mechanical ventilation,with good safety.
国家科技期刊平台
NSTL
万方数据
维普
