Predictive Analysis of New Inflammatory Markers on Heart Function in Patients with Acute Myocardial Infarction
Objective To explore the association between new inflammatory markers and heart function in patients with Acute Myocardial Infarction(AMI).Methods 174 AMI patients admitted to Xinmi City Traditional Chinese Medicine Hospital from April 2020 to April 2023 were selected.They were divided into two groups according to the heart function status within 24 hours after admission.Among them,78 patients who developed heart failure within 24 hours after admission were the heart failure group(including 36 cases of Killip Ⅱ,38 cases of Killip Ⅲ,and 4 cases of Killip Ⅳ),and 96 patients who did not develop heart failure within 24 hours after admission were the non-heart failure group.The clinical indicators of the two groups were compared,and the Spearman correlation analysis was used to analyze the relationship between new inflammatory markers and heart function;Logistic regression analysis was used to analyze the influencing factors of heart failure in AMI patients;ROC analysis was used to predict the efficacy of new inflammatory markers on heart failure in AMI patients.Results The age,multi-vessel lesion ratio,and left coronary artery lesion ratio of the heart failure group were higher than those of the non-heart failure group,and the time from onset to vascular opening was longer than that of the non-heart failure group,and the differences were statistically significant(P<0.05);The levels of Neutrophil/Lymphocyte Ratio(NLR),Platelet/Lymphocyte Ratio(PLR),Monocyte/Lymphocyte Ratio(MLR),Neutrophil/High-Density Lipoprotein Ratio(NHR),Monocyte/High-Density Lipoprotein Ratio(MHR),Creatine Kinase Isoenzyme(CK-MB),Cardiac Troponin I(cTnI),and N-terminal pro-B-type Natriuretic Peptide(NT-proBNP)in the heart failure group were all higher than those in the non-heart failure group,and the differences were statistically significant(P<0.05);The above laboratory indicators of Killip Ⅲ-Ⅳ patients were higher than those of Killip Ⅱ patients,and the differences were statistically significant(P<0.05);NLR,PLR,MLR,NHR,and MHR in the heart failure group were positively correlated with heart function grading(r=0.693,0.432,0.475,0.615,0.633,P<0.001);Logistic regression results showed that the increase of NLR,NHR,MHR,cTnI,and NT-proBNP were independent risk factors for heart failure in AMI patients;The AUC values of NLR,NHR,and MHR for predicting early heart failure in AMI patients were 0.789,0.690,and 0.765(P<0.05).Conclusion New inflammatory markers are closely related to the early heart function of AMI patients and can be used as reference indicators for predicting the heart function of AMI patients.
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