The Effect of Nasal High-Flow Heated Humidified Oxygen Therapy on Arterial Blood Gas and Vital Signs in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease(COPD)
Objective To analyze the effect of nasal high-flow heated humidified oxygen therapy on arterial blood gas and vital signs in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 104 patients with acute exacerbation of COPD admitted to Fan County People's Hospital from June 2019 to May 2021 were selected as the research subjects.Patients admitted from June 2019 to May 2020 were divided into the conventional group,and those from June 2020 to May 2021 were the HFNC group,each with 52 cases.The conventional group was given traditional nasal cannula oxygen therapy,and the HFNC group was given nasal high-flow(HFNC)oxygen therapy.The blood gas function[arterial oxygen pressure(PaO2),arterial carbon dioxide pressure(PaCO2),oxygenation index(PaO2/FiO2)],respiratory function[respiratory rate(RR),heart rate(HR),mean arterial pressure(MAP)],and sputum viscosity were compared between the two groups.Results The PaO2 and PaO2/FiO2 of the two groups increased 24 h and 72 h after intervention compared with before intervention,and the increase at 72 h was more significant,with a statistically significant difference(P＜0.05).The PaCO2 of the two groups decreased 24 h and 72 h after intervention compared with before intervention,and the decrease at 72 h was more significant,with a statistically significant difference(P＜0.05).The PaO2 and PaO2/FiO2 of the HFNC group were significantly higher than those of the conventional group at 72 h after intervention,and the PaCO2 was significantly lower than that of the conventional group,with a statistically significant difference(P＜0.05).The HR,RR,and MAP of the two groups decreased 24 h and 72 h after intervention compared with before intervention,and the decrease at 72 h was more significant,with a statistically significant difference(P＜0.05).The HR,RR,and MAP of the HFNC group were significantly lower than those of the conventional group at 72 h after intervention,with a statistically significant difference(P＜0.05).After intervention,the level Ⅲ sputum viscosity of the two groups significantly decreased compared with before intervention,and the improvement of the HFNC group was better than that of the conventional group,with a statistically significant difference(P＜0.05).Conclusion Compared with traditional oxygen therapy,HFNC can stabilize blood gas function and vital signs in patients with acute exacerbation of COPD,reduce patient's sputum viscosity,improve satisfaction and comfort,and is worth applying in clinical practice.
chronic obstructive pulmonary diseaseoxygen therapyarterial blood gas analysis
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