Study on the Effect of Nifedipine Combined with Ritodrine on the Full-Term Delivery Rate in the Treatment of Threatened Preterm Labor
Objective To study the effect of nifedipine combined with ritodrine in the treatment of threatened preterm labor on the full-term delivery rate.Methods According to the random number table method,72 patients with threatened preterm labor admitted to Pingdingshan Maternal and Child Health Hospital from February 2022 to October 2023 were divided into observation group 1(treated with nifedipine alone),observation group 2(treated with ritodrine alone)and combined group(treated with nifedipine and ritodrine),with 24 people in each group.The treatment effects,biochemical indicators,pregnancy conditions,adverse drug reactions and neonatal outcomes of the three groups of patients were observed.Results The effective rate of treatment in the combined group(91.67%)was higher than that in observation group 1(66.67%)and observation group 2(62.50%),and the difference was statistically significant(P＜0.05).After treatment,the levels of interleukin-17 and endometrial antibodies in the combined group decreased,and the indicators of transforming growth factor-β and soluble human leukocyte antigen-G increased.The difference in biochemical indicators among the three groups was statistically significant(P＜0.05).The time for uterine contractions to disappear in the combined group was shorter than that in observation group 1 and observation group 2,the pregnancy extension time was longer than that in observation group 1 and observation group 2,the delivery gestational week was later than that in observation group 1 and observation group 2,and the success rate of tocolysis in the combined group was higher than that in observation group 1 and observation group 2,the difference was statistically significant(P＜0.05).The incidence of adverse drug reactions in the combined group was compared with that in observation group 1 and observation group 2,and the difference was not statistically significant(P＞0.05).The neonatal mortality rate(8.33%)in the combined group was lower than that in observation group 1(33.33%)and observation group 2(37.50%),and the neonatal asphyxia rate(8.33%)was lower than that in observation group 1(41.67%)and observation group 2(37.50%).The neonatal Apgar score was higher than that in observation group 1 and observation group 2.The neonatal condition in the combined group was better,and the difference was statistically significant(P＜0.05).Conclusion The application of nifedipine combined with ritodrine can effectively inhibit the contraction of the patient's uterus,improve clinical symptoms and biochemical indicators,prolong pregnancy,increase the full-term delivery rate,and has high safety,avoids adverse reactions,and the neonatal condition is good,which has certain clinical application value.
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