Clinical Study on the Treatment of Post-Stroke Dysphagia with Bilateral Repetitive Transcranial Magnetic Stimulation Combined with Conventional Rehabilitation Training
Objective To investigate the therapeutic effect of bilateral repetitive transcranial magnetic stimulation(rTMS)combined with conventional rehabilitation training in patients with post-stroke dysphagia.Methods Ninety patients with post-stroke dysphagia treated at The First Affiliated Hospital of Henan University of Science and Technology from July 2021 to June 2023 were selected and randomly divided into control group,unilateral group,and bilateral group,with 30 cases in each group.All patients received conventional rehabilitation training,and in addition to that,the control group received sham rTMS,the unilateral group received rTMS stimulation on the affected side,and the bilateral group received bilateral rTMS stimulation(affected side first,followed by the unaffected side).Clinical efficacy was compared among the three groups.Results The effective rate of treatment in the bilateral group(96.67%)was higher than that in the unilateral group(90.00%)and the control group(63.33%),with statistically significant differences(P＜0.05).The post-treatment Standardized Swallowing Assessment(SSA)score in the bilateral group was lower than that in the unilateral group and the control group,with statistically significant differences(P＜0.05).The post-treatment Dysphagia Outcome and Severity Scale(DOSS)score in the bilateral group was higher than that in the unilateral group and the control group,with statistically significant differences(P＜0.05).The post-treatment levels of Neuropeptide Y(NPY),Visinin-like protein-1(VILIP-1),Fibulin-5,and Neuron-specific Enolase(NSE)in the bilateral group were lower than those in the unilateral group and the control group,with statistically significant differences(P＜0.05).Conclusion Bilateral rTMS combined with conventional rehabilitation training is effective in the treatment of post-stroke dysphagia,improving swallowing function,and reducing neurological damage.It is worthy of clinical application.
strokerehabilitation trainingrepetitive transcranial magnetic stimulationdysphagia
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