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高通量血液透析在终末期肾病治疗中的临床效果及对炎性因子的影响

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目的 研究高通量血液透析在终末期肾病治疗中的临床效果及对炎性因子的影响。方法 选取 2021 年 1 月至2023 年 3 月期间常熟东南医院诊治的 80 例终末期肾病患者,通过随机数字表法分为干预组(n=40)、常规组(n=40),常规组采用常规低通量血液透析,干预组采用高通量血液透析。期间记录并分析患者治疗前后炎性因子、心肌损伤指标、透析并发症数据。结果 治疗前两组患者炎性因子水平、心肌损伤指标差异无统计学意义(P>0。05),治疗后干预组患者炎性因子水平、心肌损伤指标均低于常规组,差异均有统计学意义(P<0。05);干预组透析并发症发生率低于常规组,差异具有统计学意义(P<0。05)。结论 在针对终末期肾病展开治疗时,选择高通量血液透析能够有效消除患者炎症水平,降低患者心肌损伤指标,具有更高的安全性,值得临床治疗中应用。
Clinical Effect of High-Flux Hemodialysis and Its Impact on Inflammatory Factors in the Treatment of End-Stage Renal Disease
Objective To study the clinical effect of high-flux hemodialysis and its impact on inflammatory factors in the treatment of end-stage renal disease.Methods A total of 80 patients with end-stage renal disease treated in Changshu Southeast Hospital from January 2021 to March 2023 were selected.They were divided into the intervention group(n=40)and the conventional group(n=40)by the random number table method.The conventional group was treated with conventional low-flux hemodialysis,and the intervention group was treated with high-flux hemodialysis.During this period,the inflammatory factors,myocardial injury indicators,and dialysis complications of the patients before and after treatment were recorded and analyzed.Results Before treatment,there was no statistically significant difference in the levels of inflammatory factors and myocardial injury indicators between the two groups of patients(P>0.05).After treatment,the levels of inflammatory factors and myocardial injury indicators in the intervention group were lower than those in the conventional group,with statistically significant differences(P<0.05).The incidence of dialysis complications in the intervention group was lower than that in the conventional group,with a statistically significant difference(P<0.05).Conclusion When treating end-stage renal disease,choosing high-flux hemodialysis can effectively reduce the level of inflammation in patients,reduce myocardial injury indicators,and has higher safety,which is worth applying in clinical treatment.

High-Flux hemodialysisEnd-Stage renal diseaseinflammatory factorsmyocardial injury indicatorscomplications

张东洋、张宁

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常熟东南医院 肾内科,江苏 苏州 215500

高通量血液透析 终末期肾病 炎性因子 心肌损伤指标 并发症

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(7)