Efficacy Analysis of Montelukast Sodium Combined with Cetirizine Hydrochloride in the Treatment of Children with Cough Variant Asthma
Objective To analyze the therapeutic effect of montelukast sodium combined with cetirizine hydrochloride in the treatment of children with cough variant asthma(CVA).Methods A total of 72 children with CVA treated in Zhengzhou Jinshui District General Hospital from June 2021 to June 2023 were selected for the study.According to different treatment methods,they were divided into two groups,each with 36 cases.The control group was treated with montelukast sodium,and the observation group was treated with cetirizine hydrochloride on the basis of the control group.The treatment effects,serum neurotrophin-3(NT-3),eosinophils(EOS),immunoglobulin E(IgE),immunoglobulin A(IgA)levels,and lung function indicators[peak expiratory flow(PEF),forced expiratory volume in the first second(FEV1),and the percentage of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)],symptom relief time,and hospital stay of the two groups were compared.Results The treatment effect of the observation group was better than that of the control group,with a statistically significant difference(P＜0.05).Before treatment,there was no statistically significant difference in EOS,NT-3,serum IgA,and IgE levels between the two groups(P＞0.05).After treatment,the EOS,NT-3,and IgE levels of the observation group were lower than those of the control group,and IgA was higher than that of the control group,with statistically significant differences(P＜0.05).Before treatment,there was no statistically significant difference in lung function indicators PEF,FEV1,and FEV1/FVC between the two groups(P＞0.05).After treatment,all lung function indicators of the observation group were higher than those of the control group,with statistically significant differences(P＜0.05).The hospital stay and symptom relief time of the observation group were significantly shorter than those of the control group,with statistically significant differences(P＜0.05).Conclusion The combined treatment of montelukast sodium and cetirizine hydrochloride for CVA can increase serum NT-3 and EOS levels,regulate serum IgA and IgE levels,improve lung function,and shorten symptom recovery time and hospital stay,which is worth applying.
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