Comparison of the Effects of Remimazolam and Propofol on Postoperative Delirium in Neurovascular Intervention Surgery under General Anesthesia
Objective To compare the effects of remimazolam and propofol on postoperative delirium in neurovascular intervention surgery under general anesthesia.Methods A total of 98 patients who underwent neurovascular intervention surgery under general anesthesia in the First Affiliated Hospital of Xinxiang Medical College from August 2021 to August 2023 were selected as the research subjects.The patients were randomly divided into the observation group and the control group,with 49 cases in each group.The patients in the observation group were given remimazolam for anesthesia,and the patients in the control group were given propofol for anesthesia.The anesthesia effect related indicators,cognitive function,brain oxygen saturation,incidence and severity of delirium in the two groups were compared.Results The recovery time of the observation group was shorter than that of the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in the post-anesthesia care unit(PACU)stay time,24-hour visual analog scale(VAS)score,and eyelash reflex disappearance time between the two groups of patients(P＞0.05).The Mini-Mental State Examination(MMSE)scores of the observation group at 12 hours and 24 hours after surgery were higher than those of the control group,with statistically significant differences(P＜0.05),but there was no statistically significant difference in the MMSE scores of the two groups at 72 hours after surgery(P＞0.05).Compared with before surgery,the MMSE scores of the two groups decreased at all time points after surgery,and the decrease became smaller with the increase of postoperative time,with statistically significant differences(P＜0.05).The brain oxygen saturation(StO2)of the observation group patients at 1 minute after induction was higher than that of the control group,with a statistically significant difference(P＜0.05).There was no statistically significant difference in StO2 between the two groups of patients before surgery and 3 minutes after induction(P＞0.05).The StO2 of the two groups of patients at 1 minute and 3 minutes after induction was lower than before surgery,with statistically significant differences(P＜0.05).The StO2 at 3 minutes after induction was lower than at 1 minute after induction,with a statistically significant difference(P＜0.05).The incidence of delirium in the observation group(4.08%)was lower than that in the control group(16.33%),with a statistically significant difference(P＜0.05).The severity of delirium was lower than that in the control group,with a statistically significant difference(P＜0.05).Conclusion Compared with giving patients undergoing neurovascular intervention surgery propofol general anesthesia,giving patients remimazolam general anesthesia can shorten the recovery time of patients,will not cause additional cognitive impairment,has less impact on brain oxygen supply during induction,and has less incidence and lighter severity of delirium.
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