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二陈汤加减治疗慢性阻塞性肺疾病痰湿蕴肺证的临床效果

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目的 探讨慢性阻塞性肺疾病(COPD)痰湿蕴肺证患者采用二陈汤加减治疗的临床效果。方法 选取 2022年 10 月至 2023 年 10 月固始县人民医院收治的 80 例COPD痰湿蕴肺证患者,以随机数字表法分成研究组(n=40)与对照组(n=40),对照组采用常规西医治疗,研究组采用二陈汤加减联合常规西药治疗,比较两组临床疗效、中医证候积分、肺功能指标及炎症因子。结果 研究组治疗有效率(97。50%)高于对照组(80。00%),差异具有统计学意义(P<0。05);两组治疗后各项中医证候积分均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0。05);两组治疗后肺总量(TLC)、第 1 秒用力呼气量(FEV1)、肺活量(FVC)、残气容积(RV)、潮气量(TV)均高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0。05);两组治疗后干扰素-γ(IFN-γ)、内皮素-1(ET-1)水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0。05)。结论 二陈汤加减治疗COPD痰湿蕴肺证能够提高临床疗效,改善中医证候以及肺功能,有效降低炎症因子水平。
Clinical Effect of Modified Erchentang in the Treatment of Chronic Obstructive Pulmonary Disease with Phlegm-Dampness Lung Syndrome
Objective To explore the clinical effect of modified Erchentang in the treatment of patients with COPD and phlegm-dampness lung syndrome.Methods 80 patients with COPD and phlegm-dampness lung syndrome who were admitted to Gushi County People's Hospital from October 2022 to October 2023 were selected.They were divided into a research group(n=40)and a control group(n=40)according to the random number table method.The control group was treated with conventional Western medicine,and the research group was treated with modified Erchentang combined with conventional Western medicine.The clinical efficacy,TCM syndrome score,lung function indicators,and inflammatory factors of the two groups were compared.Results The effective rate of treatment in the research group(97.50%)was higher than that in the control group(80.00%),and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome scores of both groups were lower than before treatment,and the research group was lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the total lung capacity(TLC),forced expiratory volume in the first second(FEV1),vital capacity(FVC),residual volume(RV),and tidal volume(TV)of both groups were higher than before treatment,and the research group was higher than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of interferon-γ(IFN-γ)and endothelin-1(ET-1)in both groups were lower than before treatment,and the research group was lower than the control group,and the differences were statistically significant(P<0.05).Conclusion The treatment of COPD with phlegm-dampness lung syndrome using modified Erchentang can improve the clinical efficacy,improve TCM syndrome and lung function,and effectively reduce the level of inflammatory factors.

modified Erchentangchronic obstructive pulmonary diseasephlegm-dampness lung syndromeclinical effect

宋海燕、汤金红、马炳莉

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固始县人民医院 呼吸与危重症医学科,河南 信阳 465200

二陈汤加减 慢性阻塞性肺疾病 痰湿蕴肺证 临床效果

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(7)