甲胎蛋白联合甲胎蛋白-L3、碱性磷酸酶和酸性水解酶检测在肝细胞癌诊断中的应用

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国家科技期刊平台
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中文摘要：目的研讨肝细胞癌诊断中应用甲胎蛋白(AFP)、碱性磷酸酶(ALP)、甲胎蛋白-L3(AFP-L3)、α-L-岩藻糖苷酶(AFU)检测的价值。方法选择南阳市中心医院 2020 年 7 月至 2023 年 7 月收治的 120 例肝细胞癌患者，设为肝细胞癌组;另选择同期入院的 120 例肝硬化患者，设为肝硬化组;再选取同期入院体检的健康者 120 例，设为健康组。予以所有研究对象AFP、ALP、AFP-L3、AFU检测，对比三组AFP、AFP-L3、ALP、AFU水平以及肝细胞癌组、肝硬化组单一AFP、AFP-L3、ALP、AFU检测和联合检测的阳性率。结果肝细胞癌组AFP、ALP、AFP-L3、AFU水平均高于肝硬化组和健康组，差异有统计学意义(P＜0。05)。肝细胞癌组中单一AFP、AFP-L3、ALP、AFU指标检测和联合检测阳性率比肝硬化组高，差异有统计学意义(P＜0。05);肝细胞癌组中四项指标联合检测阳性率 98。33%，高于单一AFP、AFP-L3、ALP、AFU指标检测的 76。67%、73。33%、41。67%、74。17%，差异有统计学意义(P＜0。05);肝硬化组中四项指标联合检测阳性率 68。33%，高于单一AFP、AFP-L3、ALP、AFU指标检测的 51。67%、5。00%、20。83%、5。83%，差异有统计学意义(P＜0。05)。结论肝细胞癌诊断中用AFP、ALP、AFP-L3、AFU检测的价值较高，值得临床应用。

外文标题：Application of Alpha-Fetoprotein Combined with Alpha-Fetoprotein-L3,Alkaline Phosphatase,and Acid Hydrolase in Hepatocellular Carcinoma

外文摘要：Objective To discuss the value of alpha-fetoprotein(AFP),alkaline phosphatase(ALP),alpha-fetoprotein-L3(AFP-L3),and α-L-fucosidase(AFU)in the diagnosis of hepatocellular carcinoma.Methods A total of 120 cases of hepatocellular carcinoma treated in Nanyang Central Hospital from July 2020 to July 2023 were selected as the hepatocellular carcinoma group.Another 120 cases of cirrhosis patients admitted to the hospital during the same period were selected as the cirrhosis group.In addition,120 healthy individuals who were admitted to the hospital for physical examination during the same period were selected as the healthy group.All research subjects were given AFP,ALP,AFP-L3,and AFU tests,and the levels of AFP,AFP-L3,ALP,and AFU in the three groups were compared,as well as the positive rate of single AFP,AFP-L3,ALP,and AFU detection and combined detection in the hepatocellular carcinoma group and the cirrhosis group.Results The levels of AFP,ALP,AFP-L3,and AFU in the hepatocellular carcinoma group were all higher than those in the cirrhosis group and the healthy group,with statistically significant differences(P＜0.05).The positive rate of single AFP,AFP-L3,ALP,and AFU detection and combined detection in the hepatocellular carcinoma group was higher than that in the cirrhosis group,with statistically significant differences(P＜0.05).The positive rate of combined detection of the four indicators in the hepatocellular carcinoma group was 98.33%,which was higher than the 76.67%,73.33%,41.67%,and 74.17%of single AFP,AFP-L3,ALP,and AFU detection,with statistically significant differences(P＜0.05).The positive rate of combined detection of the four indicators in the cirrhosis group was 68.33%,which was higher than the 51.67%,5.00%,20.83%,and 5.83%of single AFP,AFP-L3,ALP,and AFU detection,with statistically significant differences(P＜0.05).Conclusion The use of AFP,ALP,AFP-L3,and AFU in the diagnosis of hepatocellular carcinoma has a high value and is worth applying in clinical practice.

外文关键词：

hepatocellular carcinomaalpha-fetoproteinalpha-fetoprotein-L3alkaline phosphataseacid hydrolase

作者：

柴森

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作者单位：

南阳市中心医院医学检验科,河南南阳 473005

关键词：

肝细胞癌甲胎蛋白甲胎蛋白-L3 碱性磷酸酶酸性水解酶

出版年：

2024

DOI：