The Evaluation Value of Peripheral Blood sCD14,miR-140-3p,and TBIL on the Stability of Coronary Plaque in Patients with Coronary Heart Disease
Objective To explore the evaluation value of soluble CD14(sCD14),microRNA-140-3p(miR-140-3p),and total bilirubin(TBIL)in peripheral blood on the stability of coronary plaque in patients with coronary heart disease.Methods 80 patients with coronary heart disease treated in Dancheng County People's Hospital from August 2021 to August 2023 were selected as the research subjects.Intravascular ultrasound examination was performed to classify the nature of the plaque,and the patients were divided into a stable group(55 cases)and an unstable group(25 cases)according to the examination results.The general information and serum indicators of the two groups of patients were collected and compared,and variables with statistical significance were analyzed to explore the factors affecting the stability of coronary plaque in patients with coronary heart disease.Results There was no statistical significance in the comparison of age,gender,body mass index(BMI),diabetes,hypertension,urea nitrogen,creatinine,and levels of triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)in the blood between the stable group and the unstable group(P＞0.05).The level of sCD14 in the stable group was significantly lower than that in the unstable group,with a statistically significant difference(P＜0.05).The levels of miR-140-3p and TBIL were significantly higher than those in the unstable group,with statistically significant differences(P＜0.05).Logistic regression analysis showed that high levels of sCD14,low levels of miR-140-3p,and low levels of TBIL were all risk factors for the formation of unstable plaques in patients with coronary heart disease,with statistically significant differences(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that high levels of sCD14,low levels of miR-140-3p,and low levels of TBIL all had certain diagnostic value for unstable plaques,and the area under the curve(AUC)was 0.706,0.939,and 0.807,respectively,with statistically significant differences(P＜0.05).Conclusion The expression levels of sCD14,miR-140-3p,and TBIL in the peripheral blood of patients with coronary heart disease are closely related to the formation of unstable coronary plaques,and they have certain evaluation value for plaque stability.
万方数据
维普
