Analysis of the Diagnostic Value of Serum miR-182 Combined with Radionuclide Bone Imaging for Bone Metastasis in Non-Small Cell Lung Cancer
Objective To explore the diagnostic value of serum microRNA-182(miR-182)combined with radionuclide bone imaging for bone metastasis in non-small cell lung cancer(NSCLC).Methods 107 NSCLC patients with bone metastasis treated in The First People's Hospital of Nanyang City from January 2021 to January 2023 were selected as the observation group,and 105 NSCLC patients without bone metastasis were set as the control group.The clinical data,serum miR-182,and radionuclide bone imaging of the two groups of patients were compared.Logistic regression analysis was used to explore the factors affecting bone metastasis in NSCLC patients.The receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of peripheral blood miR-182 combined with radionuclide bone imaging for bone metastasis in NSCLC patients.Results There was no statistical significance in the comparison of gender,age,Body Mass Index(BMI),whether lymph node metastasis occurred,and histopathological type between the observation group and the control group(P＞0.05).The proportion of patients with tumor stage Ⅲ～Ⅳ in the observation group was higher than that in the control group,with a statistically significant difference(P＜0.05).The positive rate of serum miR-182 and radionuclide bone imaging in the observation group was higher than that in the control group,with a statistically significant difference(P＜0.05).Logistic regression analysis found that serum miR-182 and radionuclide bone imaging were risk factors affecting bone metastasis in NSCLC patients(OR=1.749,1.812,P＜0.05).ROC analysis showed that the AUC of serum miR-182,radionuclide bone imaging,and their combination for the diagnosis of bone metastasis in NSCLC patients were 0.820,0.812,and 0.916,respectively.Conclusion The abnormally high expression of miR-182 in the body of NSCLC patients and the positive radionuclide bone imaging are closely related to the occurrence of bone metastasis in patients,and the combination of the two has a high diagnostic value for bone metastasis in NSCLC patients,which can be used as an early screening indicator for bone metastasis in NSCLC patients in clinical diagnosis.
serum microrna-182radionuclide bone imagingnon-small cell lung cancerbone metastasisdiagnostic value
万方数据
维普
