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肺泡灌洗联合纤维支气管镜吸痰治疗重症肺炎的临床效果

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目的 探讨重症肺炎(SP)患者采用肺泡灌洗联合纤维支气管镜(FOB)吸痰治疗的临床效果。方法 选取2019 年 7 月至 2024 年 4 月在河南省三门峡市陕州区第一人民医院接受治疗的 60 例SP患者,以随机数字表法分为研究组(n=30)与对照组(n=30),两组均给予对症治疗,对照组采用常规吸痰治疗,研究组采用肺泡灌洗联合FOB吸痰治疗,比较两组临床疗效、血气分析指标、炎性指标、呼吸功能、疾病严重程度、临床指标。结果 研究组治疗有效率(93。33%)高于对照组(73。33%),差异具有统计学意义(P<0。05);两组治疗后动脉血氧饱和度(SaO2)、动脉血氧分压(PaO2)、pH值、氧合指数(PaO2/FiO2)较治疗前升高,动脉血二氧化碳分压(PaCO2)较治疗前下降,差异具有统计学意义(P<0。05),治疗后研究组PaO2、SaO2、pH值、PaO2/FiO2 水平高于对照组,PaCO2 水平低于对照组,差异具有统计学意义(P<0。05);两组治疗后降钙素原(PCT)、白细胞计数(WBC)、C反应蛋白(CRP)水平较治疗前下降,差异具有统计学意义(P<0。05),治疗后研究组PCT、WBC、CRP水平低于对照组,差异具有统计学意义(P<0。05);两组治疗后呼吸功(WOB)、临床肺部感染评分(CPIS)、急性生理与慢性健康系统Ⅱ(APACHEⅡ)评分较治疗前下降,差异具有统计学意义(P<0。05),治疗后研究组WOB水平、CPIS、APACHEⅡ评分低于对照组,差异具有统计学意义(P<0。05);研究组肺部湿啰音消失、咳嗽消失、退热、机械通气、ICU监护时间短于对照组,差异具有统计学意义(P<0。05)。结论 肺泡灌洗联合FOB吸痰应用于SP治疗中,能够提升临床疗效,改善呼吸功能、血气分析指标,缓解炎症反应,减轻症状效果,缩短患者康复时间,值得临床应用。
Clinical Effect of Alveolar Lavage Combined with Fiberoptic Bronchoscopy Sputum Suction in the Treatment of Severe Pneumonia
Objective To explore the clinical effect of alveolar lavage combined with fiberoptic bronchoscopy(FOB)sputum suction in the treatment of severe pneumonia(SP)patients.Methods 60 SP patients treated in The First People's Hospital of Shanxian County,Sanmenxia City,Henan Province from July 2019 to April 2024 were selected.They were divided into a research group(n=30)and a control group(n=30)according to the random number table method.Both groups were given symptomatic treatment.The control group was treated with routine sputum suction,and the research group was treated with alveolar lavage combined with FOB sputum suction.The clinical efficacy,blood gas analysis indicators,inflammatory indicators,respiratory function,disease severity,and clinical indicators of the two groups were compared.Results The effective rate of treatment in the research group(93.33%)was higher than that in the control group(73.33%),and the difference was statistically significant(P<0.05).After treatment,the arterial blood oxygen saturation(SaO2),arterial blood oxygen partial pressure(PaO2),pH value,and oxygenation index(PaO2/FiO2)of the two groups were higher than before treatment,and the arterial blood carbon dioxide partial pressure(PaCO2)was lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the PaO2,SaO2,pH value,and PaO2/FiO2 levels of the research group were higher than those of the control group,and the PaCO2 level was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the procalcitonin(PCT),white blood cell count(WBC),and C-reactive protein(CRP)levels of the two groups were lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the PCT,WBC,and CRP levels of the research group were lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,the work of breathing(WOB),clinical pulmonary infection score(CPIS),and acute physiology and chronic health evaluation II(APACHE II)score of the two groups were lower than before treatment,and the difference was statistically significant(P<0.05).After treatment,the WOB level,CPIS,and APACHE II score of the research group were lower than those of the control group,and the difference was statistically significant(P<0.05).The disappearance of lung wet rales,cough,fever,mechanical ventilation,and ICU care time in the research group were shorter than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The application of alveolar lavage combined with FOB sputum suction in the treatment of SP can improve the clinical efficacy,improve respiratory function,blood gas analysis indicators,alleviate inflammatory response,reduce symptom effects,shorten patient recovery time,and is worth clinical application.

alveolar lavagefiberoptic bronchoscope sputum suctionsevere pneumoniaclinical effect

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河南省三门峡市陕州区第一人民医院 呼吸内科,河南 三门峡 472100

肺泡灌洗 纤维支气管镜吸痰 重症肺炎 临床效果

2024

临床研究
西安交通大学

临床研究

影响因子:0.234
ISSN:2096-1278
年,卷(期):2024.32(8)