Effect of Continuous Administration of Mifepristone and Modified Short-Cycle Therapy on Perimenopausal Dysfunctional Uterine Bleeding
Objective To explore the effects of continuous administration of mifepristone and modified short-cycle therapy on patients with perimenopausal dysfunctional uterine bleeding.Methods Seventy-six patients with perimenopausal dysfunctional uterine bleeding treated at Donghedian Town Central Health Center,Pingyu County,from August 2021 to August 2023 were randomly divided into two groups,with 38 cases in each group.Both groups were treated with mifepristone,with the control group receiving continuous administration and the observation group receiving modified short-cycle therapy.The uterine ultrasound indicators,sex hormone levels,incidence of adverse reactions,recurrence,and occurrence of amenorrhea were compared between the two groups.Results Before treatment,there were no statistically significant differences in uterine volume and endometrial thickness between the two groups(P＞0.05).After treatment,both uterine volume and endometrial thickness were reduced in both groups,with the observation group showing a more significant reduction compared to the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of estradiol,progesterone,and follicle-stimulating hormone in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).The incidence of adverse reactions in the observation group(2.63%)was lower than that in the control group(18.42%),with statistically significant differences(P＜0.05).Follow-up results showed that the recurrence rate and incidence of amenorrhea in the observation group were lower than those in the control group,with statistically significant differences(P＜0.05).Conclusion Compared to continuous administration of mifepristone,the modified short-cycle therapy can effectively ensure uterine health,alleviate uterine bleeding,and significantly reduce the recurrence rate and incidence of amenorrhea.
万方数据
维普
