The Impact of Dexmedetomidine Combined with Nalbuphine Analgesic Regimen on Patients Undergoing Laparoscopic Cholecystectomy
Objective To explore the application effect of dexmedetomidine combined with nalbuphine analgesic regimen in patients undergoing laparoscopic cholecystectomy.Methods From January 2021 to January 2023,94 patients who underwent laparoscopic surgery in the People's Hospital of Huojia County were selected.They were divided into a control group(anesthesia induction+maintenance anesthesia+dexmedetomidine analgesia)and an observation group(dexmedetomidine analgesia combined with nalbuphine analgesic regimen)with 47 cases each using a random number table method.The clinical indicators,hemodynamics,coagulation function,pain score[Visual Analogue Scale(VAS)],Ramsay sedation score,Mini-Mental State Examination(MMSE),stress response,and complication incidence rate of the two groups were compared.Results The extubation time,eye-opening time,and orientation recovery time of the observation group were shorter than those of the control group,and the difference was statistically significant(P＜0.05).After 24 hours of surgery,the heart rate(HR),systolic blood pressure(SBP),and diastolic blood pressure(DBP)of the observation group were lower than those of the control group,and the difference was statistically significant(P＜0.05).The D-dimer(DD)and fibrinogen(FIB)of the control group were lower than those of the observation group 7 days after surgery,and the difference was statistically significant(P＜0.05);there was no statistical significance in the comparison of activated partial thromboplastin time(APTT)and prothrombin time(PT)between the two groups(P＞0.05).The VAS,Ramsay,and MMSE scores of the observation group were better than those of the control group,and the difference was statistically significant(P＜0.05).The superoxide dismutase(SOD)and malondialdehyde(MDA)of the observation group were lower than those of the control group after extubation,and the difference was statistically significant(P＜0.05);the total antioxidant capacity(T-AOC)of the control group was lower than that of the observation group,and the difference was statistically significant(P＜0.05).The incidence rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The use of dexmedetomidine combined with nalbuphine analgesic regimen in laparoscopic cholecystectomy has a significant anesthetic effect,can stabilize hemodynamics,reduce pain and the incidence of complications,has less impact on coagulation function,reduces stress response,and protects patients'cognitive function.
dexmedetomidinenalbuphine analgesic regimenlaparoscopic cholecystectomycognitive function
万方数据
维普
