Comparison of the Therapeutic Effects of Valsartan and Benazepril Combined with Amiodarone in the Treatment of Primary Hypertension Complicated with Chronic Heart Failure
Objective To explore the therapeutic effects of valsartan combined with amiodarone and benazepril combined with amiodarone in patients with Essential Hypertension(EH)complicated with chronic heart failure(CHF).Methods 90 patients with EH complicated with CHF treated in the Affiliated Hospital of Jiaozuo Health Medical College from January 2021 to December 2022 were selected as the research subjects and randomly divided into group A(n=45)and group B(n=45).Patients in group A were treated with valsartan combined with amiodarone,and patients in group B were treated with benazepril combined with amiodarone.The blood pressure,heart function indicators,serum inflammatory factors,myocardial injury indicators of the two groups before and 3 months after treatment were compared;the incidence of drug adverse reactions during treatment in the two groups was compared.Results 3 months after treatment,the daily morning left upper limb systolic blood pressure(SBP)and diastolic blood pressure(DBP)levels of both groups were significantly lower than before treatment,and group A was lower than group B,with statistically significant differences(P＜0.05).3 months after treatment,the left ventricular end-diastolic volume(LVEDV)level of both groups was significantly lower than before treatment,and the left ventricular ejection fraction(LVEF)was significantly higher than before treatment,with statistically significant differences(P＜0.05),and the LVEF level of group A was significantly higher than that of group B,with statistically significant differences(P＜0.05),but there was no statistically significant difference in the LVEDV level between group A and group B(P＞0.05).3 months after treatment,the serum interleukin-1(IL-1),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),cardiac troponin I(cTnI),and B-type natriuretic peptide(BNP)levels of both groups were significantly lower than before treatment,and group A was lower than group B,with statistically significant differences(P＜0.05).There was no statistically significant difference in the incidence of drug adverse reactions during treatment between the two groups(P＞0.05).Conclusion Compared with benazepril combined with amiodarone,valsartan combined with amiodarone has outstanding effects in the treatment of EH complicated with CHF,can further improve the heart function of patients,inhibit inflammatory response,restore myocardial injury,and is safe in medication.
万方数据
维普
